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IID50193
 UniprotO35718
ProteinSuppressor of cytokine signaling 3
GeneSocs3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
225
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 15-185 Hetero dimer : IID50222Complex
 Evidence NMR 2bbu A Reference
       Region 2bbu A 22-29 disorder
       Region 2bbu A 30-185 order
       Region 2bbu A 75-77 high_rmsd
       Region 2bbu A 106-118 high_rmsd
       Region 2bbu A 131-162 high_rmsd
       Region 2bbu A 185-185 high_rmsd
 Evidence X-RAY 2hmh A Reference
       Region 2hmh A 15-28 disorder
       Region 2hmh A 29-130 order
       Region 2hmh A 154-154 order
       Region 2hmh A 155-163 disorder
       Region 2hmh A 164-168 order
       Region 2hmh A 169-172 disorder
       Region 2hmh A 173-185 order
Seqdisorder 22-29
 Evidence X-RAY Reference
       Region 22-29 disorder
Seq 22-128,163-185 Hetero trimer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 F Reference
       Region 4gl9 F 22-128 order
       Region 4gl9 F 163-163 disorder
       Region 4gl9 F 164-168 order
       Region 4gl9 F 169-171 disorder
       Region 4gl9 F 172-184 order
       Region 4gl9 F 185-185 disorder
Seq 22-128,163-185 Hetero trimer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 H Reference
       Region 4gl9 H 22-128 order
       Region 4gl9 H 163-163 disorder
       Region 4gl9 H 164-168 order
       Region 4gl9 H 169-171 disorder
       Region 4gl9 H 172-184 order
       Region 4gl9 H 185-185 disorder
Seq 22-128,163-185 Hetero trimer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 G Reference
       Region 4gl9 G 22-128 order
       Region 4gl9 G 163-163 disorder
       Region 4gl9 G 164-168 order
       Region 4gl9 G 169-171 disorder
       Region 4gl9 G 172-184 order
       Region 4gl9 G 185-185 disorder
Seq 22-128,163-185 Hetero trimer : IID50091Complex,IID50222Complex
 Evidence X-RAY 4gl9 E Reference
       Region 4gl9 E 22-128 order
       Region 4gl9 E 163-163 disorder
       Region 4gl9 E 164-168 order
       Region 4gl9 E 169-171 disorder
       Region 4gl9 E 172-184 order
       Region 4gl9 E 185-185 disorder
Seqdisorder 22-225
 Evidence NMR Reference
       Region 22-225 disorder
Seq 186-225 Hetero trimer : IID50219Complex
 Evidence NMR 2jz3 A Reference
       Region 2jz3 A 186-200 order
       Region 2jz3 A 201-225 disorder
SeqProS verified 22-29 Hetero trimer : IID50091Complex,IID50222Complex
       Region 4gl9 F 22-128 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero trimer : IID50091Complex,IID50222Complex
       Region 4gl9 G 22-128 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero trimer : IID50091Complex,IID50222Complex
       Region 4gl9 E 22-128 order
       Region 22-29 disorder
SeqProS verified 22-29 Hetero trimer : IID50091Complex,IID50222Complex
       Region 4gl9 H 22-128 order
       Region 22-29 disorder
SeqProS verified 186-200 Hetero trimer : IID50219Complex
       Region 2jz3 A 186-200 order
       Region 22-225 disorder
 
Prediction
NeProc
Disorder 1-21,140-161
Order 22-139,162-225
ProS 1-7,18-21
AlphaFold
Disorder 1-24,108-113,129-164,170-170,199-208,210-210,220-225
Order 25-107,114-128,165-169,171-198,209-209,211-219
Pfam Hmmer
PF00017 46-127 6.6e-08
PF07525 186-222 5.2e-09
SEG 129-141
Function
Function in SwissProt
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors (PubMed:10821852, PubMed:12754505, PubMed:9889194). Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling (PubMed:12754505, PubMed:9889194). Suppresses fetal liver erythropoiesis (PubMed:10490101). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (PubMed:12847520). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).