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IID50195
 UniprotO70239
ProteinAxin-1
GeneAxin1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
827
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 743-827 Monomer :
 Evidence X-RAY 2d5g F Reference
       Region 2d5g F 743-744 disorder
       Region 2d5g F 745-827 order
 Evidence X-RAY 2d5g E Reference
       Region 2d5g E 743-747 disorder
       Region 2d5g E 748-827 order
 Evidence X-RAY 2d5g D Reference
       Region 2d5g D 743-744 disorder
       Region 2d5g D 745-827 order
 Evidence X-RAY 2d5g C Reference
       Region 2d5g C 743-744 disorder
       Region 2d5g C 745-827 order
 Evidence X-RAY 2d5g B Reference
       Region 2d5g B 743-827 order
 Evidence X-RAY 2d5g A Reference
       Region 2d5g A 743-744 disorder
       Region 2d5g A 745-827 order
Seq 744-827 Homo trimer :
 Evidence X-RAY 1wsp C Reference
       Region 1wsp C 744-827 order
 Evidence X-RAY 1wsp B Reference
       Region 1wsp B 744-827 order
 Evidence X-RAY 1wsp A Reference
       Region 1wsp A 744-744 disorder
       Region 1wsp A 745-827 order
Seqphosphorylation
    509-509 Phosphoserine
    578-578 Phosphoserine
    75-75 Phosphoserine; by CK1
    492-492 Phosphoserine
    485-485 Phosphoserine; by GSK3-beta
    480-480 Phosphothreonine; by GSK3-beta
    468-468 Phosphoserine; by CK1
    217-217 Phosphoserine; by CK1
    77-77 Phosphoserine; by CK1
 
Prediction
NeProc
Disorder 1-80,214-388,427-707,736-745
Order 81-130,135-213,389-426,708-735,746-827
ProS 4-39,59-73,239-250,284-322,329-344,353-388,448-484,517-525,544-579,623-642,672-677,688-692,704-707
AlphaFold
Disorder 1-77,214-241,246-269,271-348,363-382,420-464,481-620,639-692,723-745
Order 78-213,242-245,270-270,349-362,383-419,465-480,621-638,693-722,746-827
Pfam Hmmer
PF00615 88-211 5.3e-07
PF00778 745-827 9.7e-47
SEG 225-236 ,325-339 ,401-421 ,528-539 ,694-704 ,708-722
Function
Function in SwissProt
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (By similarity). Also facilitates the phosphorylation of APC by GSK3B (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).