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IID50197
 UniprotP07313
ProteinMyosin light chain kinase 2, skeletal/cardiac muscle
GeneMYLK2
OrganismOryctolagus cuniculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
608
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 578-603
 Evidence NMR Reference
       Region 578-603 disorder
Seq 578-603 Hetero dimer : IID50080Complex
 Evidence NMR 2bbn B Reference
       Region 2bbn B 578-579 disorder
       Region 2bbn B 578-578 high_rmsd
       Region 2bbn B 580-598 order
       Region 2bbn B 599-603 disorder
       Region 2bbn B 601-603 high_rmsd
 Evidence NMR 2bbm B Reference
       Region 2bbm B 578-579 disorder
       Region 2bbm B 580-598 order
       Region 2bbm B 599-603 disorder
SeqProS verified 580-598 Hetero dimer : IID50080Complex
       Region 2bbm B 580-598 order
       Region 2bbn B 580-598 order
       Region 578-603 disorder
Seqphosphorylation
    159-159 Phosphoserine
    153-153 Phosphoserine
    457-457 Phosphothreonine
    161-161 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-275,594-608
Order 276-593
ProS 1-10,132-142,155-165,190-209,217-240,246-258,263-275,594-597,604-608
AlphaFold
Disorder 1-271,305-308,452-456,598-608
Order 272-304,309-451,457-597
Pfam Hmmer
PF00069 297-552 3.9e-82
SEG 32-47 ,75-92 ,111-129 ,187-206 ,273-280
Function
Function in SwissProt
Implicated in the level of global muscle contraction and cardiac function (By similarity). Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Biological Process
Diagram with PDB data
MYLK2/CALM1SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR