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IID50199
 UniprotP15379
ProteinCD44 antigen
GeneCd44
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
778
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-174 Monomer :
 Evidence X-RAY 4np3 A Reference
       Region 4np3 A 23-171 order
 Evidence X-RAY 4np2 A Reference
       Region 4np2 A 23-171 order
 Evidence X-RAY 4mrh A Reference
       Region 4mrh A 23-171 order
 Evidence X-RAY 4mrg A Reference
       Region 4mrg A 23-171 order
 Evidence X-RAY 4mrf A Reference
       Region 4mrf A 23-171 order
 Evidence X-RAY 4mre A Reference
       Region 4mre A 23-171 order
 Evidence X-RAY 4mrd A Reference
       Region 4mrd A 23-171 order
 Evidence X-RAY 2jcr A Reference
       Region 2jcr A 23-171 order
       Region 2jcr A 172-174 disorder
 Evidence X-RAY 2jcq A Reference
       Region 2jcq A 23-171 order
       Region 2jcq A 172-174 disorder
 Evidence X-RAY 2jcp A Reference
       Region 2jcp A 23-171 order
       Region 2jcp A 172-174 disorder
 Evidence X-RAY 5bzt A Reference
       Region 5bzt A 21-21 disorder
       Region 5bzt A 22-171 order
 Evidence X-RAY 5bzs A Reference
       Region 5bzs A 21-21 disorder
       Region 5bzs A 22-171 order
 Evidence X-RAY 5bzr A Reference
       Region 5bzr A 21-21 disorder
       Region 5bzr A 22-171 order
 Evidence X-RAY 5bzq A Reference
       Region 5bzq A 21-21 disorder
       Region 5bzq A 22-171 order
 Evidence X-RAY 5bzp A Reference
       Region 5bzp A 21-21 disorder
       Region 5bzp A 22-171 order
 Evidence X-RAY 5bzo A Reference
       Region 5bzo A 21-21 disorder
       Region 5bzo A 22-171 order
 Evidence X-RAY 5bzn A Reference
       Region 5bzn A 21-21 disorder
       Region 5bzn A 22-171 order
 Evidence X-RAY 5bzm A Reference
       Region 5bzm A 21-21 disorder
       Region 5bzm A 22-171 order
 Evidence X-RAY 5bzl A Reference
       Region 5bzl A 21-21 disorder
       Region 5bzl A 22-171 order
 Evidence X-RAY 5bzk A Reference
       Region 5bzk A 21-21 disorder
       Region 5bzk A 22-171 order
 Evidence X-RAY 5bzj A Reference
       Region 5bzj A 21-21 disorder
       Region 5bzj A 22-171 order
 Evidence X-RAY 5bzi A Reference
       Region 5bzi A 21-21 disorder
       Region 5bzi A 22-171 order
 Evidence X-RAY 5bzh A Reference
       Region 5bzh A 21-21 disorder
       Region 5bzh A 22-171 order
 Evidence X-RAY 5bzg A Reference
       Region 5bzg A 21-21 disorder
       Region 5bzg A 22-171 order
 Evidence X-RAY 5bzf A Reference
       Region 5bzf A 21-21 disorder
       Region 5bzf A 22-171 order
 Evidence X-RAY 5bze A Reference
       Region 5bze A 23-171 order
 Evidence X-RAY 5bzc A Reference
       Region 5bzc A 22-171 order
Seq 708-727 Hetero dimer : IID50114Complex
 Evidence X-RAY 2zpy B Reference
       Region 2zpy B 708-713 disorder
       Region 2zpy B 714-722 order
       Region 2zpy B 723-727 disorder
Seqphosphorylation
    726-726 Phosphothreonine
    733-733 Phosphoserine
    742-742 Phosphoserine
    708-708 Phosphoserine; by PKC
 
Prediction
NeProc
Disorder 1-19,135-685,709-778
Order 20-133,686-708
ProS 1-19,135-161,193-223,242-248,257-260,281-288,328-334,354-377,385-390,398-406,435-444,458-463,482-496,515-535,557-564,569-585,591-612,628-643,652-659,681-685,709-727,735-778
AlphaFold
Disorder 1-2,16-21,174-682,711-778
Order 3-15,22-173,683-710
Pfam Hmmer
PF00193 33-122 1.4e-39
SEG 249-274 ,315-328 ,427-437 ,638-651 ,687-701
Function
Function in SwissProt
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:8343954, PubMed:25065622). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (By similarity).