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IID50205
 UniprotP26039
ProteinTalin-1
GeneTln1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2541
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-85 Monomer :
 Evidence NMR 2kc1 A Reference
       Region 2kc1 A 1-34 order
       Region 2kc1 A 35-45 disorder
       Region 2kc1 A 46-50 order
       Region 2kc1 A 51-59 disorder
       Region 2kc1 A 60-85 order
Seq 1-86 Hetero dimer : P61224
 Evidence NMR 6ba6 A Reference
       Region 6ba6 A 1-86 order
Seq 1-138,169-202 Monomer :
 Evidence NMR 2kma A Reference
       Region 2kma A 1-138 order
       Region 2kma A 169-202 order
       Region 2kma A 172-172 high_rmsd
Seq 1-138,168-400 Monomer :
 Evidence X-RAY 3ivf A Reference
       Region 3ivf A 1-1 disorder
       Region 3ivf A 2-133 order
       Region 3ivf A 134-138 disorder
       Region 3ivf A 168-172 disorder
       Region 3ivf A 173-398 order
       Region 3ivf A 399-400 disorder
Seq 86-202 Monomer :
 Evidence NMR 2kc2 A Reference
       Region 2kc2 A 86-202 order
       Region 2kc2 A 135-166 high_rmsd
       Region 2kc2 A 198-202 high_rmsd
Seqdisorder 145-168
 Evidence CD Reference
       Region 145-168 disorder
Seq 206-405,1654-1847 Hetero dimer :
 Evidence X-RAY 4f7g B Reference
       Region 4f7g B 1654-1654 disorder
       Region 4f7g B 1655-1824 order
       Region 4f7g B 1825-1847 disorder
 Evidence X-RAY 4f7g A Reference
       Region 4f7g A 206-208 disorder
       Region 4f7g A 209-400 order
       Region 4f7g A 401-405 disorder
Seq 209-410 Hetero dimer : IID50194Complex
 Evidence X-RAY 1y19 L Reference
       Region 1y19 L 209-400 order
       Region 1y19 L 401-410 disorder
 Evidence X-RAY 1y19 J Reference
       Region 1y19 J 209-400 order
       Region 1y19 J 401-410 disorder
 Evidence X-RAY 1y19 H Reference
       Region 1y19 H 209-400 order
       Region 1y19 H 401-410 disorder
 Evidence X-RAY 1y19 F Reference
       Region 1y19 F 209-400 order
       Region 1y19 F 401-410 disorder
 Evidence X-RAY 1y19 D Reference
       Region 1y19 D 209-400 order
       Region 1y19 D 401-410 disorder
 Evidence X-RAY 1y19 B Reference
       Region 1y19 B 209-400 order
       Region 1y19 B 401-410 disorder
Seq 305-404 Hetero dimer : IID00359Complex
 Evidence NMR 2g35 A Reference
       Region 2g35 A 305-404 order
Seq 311-401,1655-1822 Hetero dimer :
 Evidence NMR 2kgx B Reference
       Region 2kgx B 311-401 order
 Evidence NMR 2kgx A Reference
       Region 2kgx A 1655-1822 order
Seqdisorder 316-326
 Evidence NMR Reference
       Region 316-326 disorder
Seqdisorder 400-480
 Evidence NMR Reference
       Region 400-480 disorder
Seq 482-655 Monomer :
 Evidence X-RAY 1sj7 C Reference
       Region 1sj7 C 482-488 disorder
       Region 1sj7 C 489-654 order
       Region 1sj7 C 655-655 disorder
 Evidence X-RAY 1sj7 B Reference
       Region 1sj7 B 482-484 disorder
       Region 1sj7 B 485-654 order
       Region 1sj7 B 655-655 disorder
 Evidence X-RAY 1sj7 A Reference
       Region 1sj7 A 482-487 disorder
       Region 1sj7 A 488-654 order
       Region 1sj7 A 655-655 disorder
Seq 482-789 Monomer :
 Evidence X-RAY 1sj8 A Reference
       Region 1sj8 A 482-485 disorder
       Region 1sj8 A 486-782 order
       Region 1sj8 A 783-789 disorder
Seq 605-628 Hetero dimer : P12003
 Evidence X-RAY 1t01 B Reference
       Region 1t01 B 605-628 order
Seqdisorder 635-654
 Evidence NMR Reference
       Region 635-654 disorder
Seq 755-889 Monomer :
 Evidence NMR 1u89 A Reference
       Region 1u89 A 755-889 order
       Region 1u89 A 755-760 high_rmsd
       Region 1u89 A 791-794 high_rmsd
       Region 1u89 A 880-889 high_rmsd
Seq 787-911 Monomer :
 Evidence NMR 2l7a A Reference
       Region 2l7a A 787-911 order
       Region 2l7a A 787-795 high_rmsd
       Region 2l7a A 911-911 high_rmsd
Seq 913-1044 Monomer :
 Evidence NMR 2lqg A Reference
       Region 2lqg A 913-1044 order
       Region 2lqg A 941-948 high_rmsd
Seq 1046-1207 Monomer :
 Evidence NMR 2l7n A Reference
       Region 2l7n A 1046-1207 order
       Region 2l7n A 1046-1047 high_rmsd
       Region 2l7n A 1108-1113 high_rmsd
       Region 2l7n A 1207-1207 high_rmsd
Seq 1206-1357 Monomer :
 Evidence NMR 2l10 A Reference
       Region 2l10 A 1206-1357 order
       Region 2l10 A 1230-1232 high_rmsd
       Region 2l10 A 1356-1357 high_rmsd
Seq 1357-1657 Hetero dimer : Q8R5A3
 Evidence X-RAY 4w8p A Reference
       Region 4w8p A 1357-1657 order
Seq 1357-1822 Monomer :
 Evidence X-RAY 5ic1 A Reference
       Region 5ic1 A 1357-1819 order
       Region 5ic1 A 1820-1822 disorder
 Evidence X-RAY 5ic0 A Reference
       Region 5ic0 A 1357-1819 order
       Region 5ic0 A 1820-1822 disorder
Seq 1359-1659 Monomer :
 Evidence X-RAY 2x0c A Reference
       Region 2x0c A 1359-1659 order
Seq 1359-1659 Hetero dimer : IID00677Complex
 Evidence X-RAY 5fzt A Reference
       Region 5fzt A 1359-1659 order
Seq 1512-1546 Hetero dimer : P18206
 Evidence X-RAY 3s90 D Reference
       Region 3s90 D 1512-1519 disorder
       Region 3s90 D 1520-1545 order
       Region 3s90 D 1546-1546 disorder
 Evidence X-RAY 3s90 C Reference
       Region 3s90 C 1512-1519 disorder
       Region 3s90 C 1520-1546 order
Seq 1628-1652 Hetero dimer : P12003
 Evidence X-RAY 1zw3 B Reference
       Region 1zw3 B 1628-1629 disorder
       Region 1zw3 B 1630-1652 order
Seq 1655-1822 Monomer :
 Evidence NMR 2kbb A Reference
       Region 2kbb A 1655-1822 order
Seq 1815-1973 Monomer :
 Evidence NMR 2kvp A Reference
       Region 2kvp A 1815-1973 order
       Region 2kvp A 1815-1822 high_rmsd
       Region 2kvp A 1973-1973 high_rmsd
 Evidence NMR 2b0h A Reference
       Region 2b0h A 1843-1973 order
       Region 2b0h A 1843-1846 high_rmsd
       Region 2b0h A 1973-1973 high_rmsd
Seq 1974-2293 Monomer :
 Evidence X-RAY 3dyj B Reference
       Region 3dyj B 1974-1974 disorder
       Region 3dyj B 1975-2291 order
       Region 3dyj B 2292-2293 disorder
 Evidence X-RAY 3dyj A Reference
       Region 3dyj A 1974-1974 disorder
       Region 3dyj A 1975-2291 order
       Region 3dyj A 2292-2293 disorder
Seq 2300-2482 Monomer :
 Evidence NMR 2jsw A Reference
       Region 2jsw A 2300-2482 order
       Region 2jsw A 2331-2336 high_rmsd
       Region 2jsw A 2482-2482 high_rmsd
Seq 2494-2541 Homo dimer :
 Evidence X-RAY 2qdq B Reference
       Region 2qdq B 2494-2496 disorder
       Region 2qdq B 2497-2529 order
       Region 2qdq B 2530-2541 disorder
 Evidence X-RAY 2qdq A Reference
       Region 2qdq A 2494-2495 disorder
       Region 2qdq A 2496-2529 order
       Region 2qdq A 2530-2541 disorder
SeqProS verified 316-326 This region is ordered in the complex with another region of this protein. Hetero dimer :
       Region 2kgx B 311-401 order
       Region 316-326 disorder
Seqphosphorylation
    2040-2040 Phosphoserine
    1878-1878 Phosphoserine
    1855-1855 Phosphothreonine
    1849-1849 Phosphoserine
    1323-1323 Phosphoserine
    1328-1328 Phosphoserine
    1263-1263 Phosphothreonine
    1201-1201 Phosphoserine
    1225-1225 Phosphoserine
    1142-1142 Phosphothreonine
    1021-1021 Phosphoserine
    1116-1116 Phosphotyrosine
    729-729 Phosphoserine
    620-620 Phosphoserine
    446-446 Phosphoserine
    425-425 Phosphoserine
    405-405 Phosphoserine
    167-167 Phosphothreonine
Seqacetylation
    2115-2115 N6-acetyllysine
    2031-2031 N6-acetyllysine
    1544-1544 N6-acetyllysine
 
Prediction
NeProc
Disorder 135-159,411-484,712-723,789-796,940-951,1106-1114,1226-1264,1411-1417,1841-1848,1866-1875,2004-2104,2280-2307,2316-2322,2329-2336,2364-2380,2484-2493,2529-2541
Order 1-134,160-318,324-410,485-629,634-692,698-711,724-788,797-939,952-1105,1115-1225,1265-1292,1298-1410,1418-1453,1458-1484,1492-1840,1849-1865,1876-2003,2105-2279,2308-2315,2323-2328,2337-2363,2381-2483,2494-2528
ProS 141-159,418-466,473-484,717-723,940-951,1106-1114,1226-1259,1411-1417,1841-1841,1866-1873,2004-2104,2280-2288,2294-2307,2316-2322,2329-2336,2364-2374,2484-2493,2529-2535
AlphaFold
Disorder 1-3,12-12,38-44,55-58,93-95,121-125,132-172,196-211,274-274,375-375,400-486,517-519,521-521,601-601,786-800,816-817,843-853,855-855,881-881,905-913,944-951,1045-1048,1204-1205,1224-1233,1355-1359,1456-1460,1482-1482,1484-1486,1517-1517,1579-1580,1582-1586,1691-1692,1842-1845,1971-1971,1973-1974,2103-2103,2106-2106,2163-2164,2292-2302,2326-2339,2341-2342,2374-2388,2415-2420,2445-2445,2448-2448,2476-2508,2513-2513,2521-2521,2524-2524,2527-2541
Order 4-11,13-37,45-54,59-92,96-120,126-131,173-195,212-273,275-374,376-399,487-516,520-520,522-600,602-785,801-815,818-842,854-854,856-880,882-904,914-943,952-1044,1049-1203,1206-1223,1234-1354,1360-1455,1461-1481,1483-1483,1487-1516,1518-1578,1581-1581,1587-1690,1693-1841,1846-1970,1972-1972,1975-2102,2104-2105,2107-2162,2165-2291,2303-2325,2340-2340,2343-2373,2389-2414,2421-2444,2446-2447,2449-2475,2509-2512,2514-2520,2522-2523,2525-2526
Pfam Hmmer
PF00373 121-313 4.5e-111
PF01608 2341-2533 6.2e-109
SEG 401-406 ,671-690 ,766-775 ,866-879 ,884-895 ,919-946 ,981-995 ,1311-1323 ,1677-1688 ,1817-1828 ,2305-2327 ,2348-2366 ,2506-2523
Function
Function in SwissProt
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.