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IID50213
 UniprotP54939
ProteinTalin-1
GeneTLN1
OrganismGallus gallus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2541
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 189-309 Monomer :
 Evidence NMR 2hrj A Reference
       Region 2hrj A 189-309 order
       Region 2hrj A 189-202 high_rmsd
       Region 2hrj A 309-309 high_rmsd
Seq 196-400 Monomer :
 Evidence X-RAY 1mix A Reference
       Region 1mix A 196-400 order
Seq 200-400 Hetero dimer : P05106
 Evidence X-RAY 1mk9 F Reference
       Region 1mk9 F 209-398 order
       Region 1mk9 F 399-400 disorder
 Evidence X-RAY 1mk9 H Reference
       Region 1mk9 H 209-318 order
       Region 1mk9 H 319-322 disorder
       Region 1mk9 H 323-400 order
 Evidence X-RAY 1mk9 B Reference
       Region 1mk9 B 209-321 order
       Region 1mk9 B 322-324 disorder
       Region 1mk9 B 325-398 order
       Region 1mk9 B 399-400 disorder
 Evidence X-RAY 1mk9 D Reference
       Region 1mk9 D 209-400 order
 Evidence X-RAY 1mk7 B Reference
       Region 1mk7 B 209-400 order
 Evidence X-RAY 1mk7 D Reference
       Region 1mk7 D 209-318 order
       Region 1mk7 D 319-323 disorder
       Region 1mk7 D 324-400 order
 Evidence X-RAY 1miz B Reference
       Region 1miz B 200-400 order
Seq 309-400 Hetero dimer : IID50232Complex
 Evidence NMR 2k00 A Reference
       Region 2k00 A 309-400 order
Seq 309-405 Hetero dimer : IID50194Complex
 Evidence NMR 2h7e A Reference
       Region 2h7e A 309-405 order
 Evidence NMR 2h7d A Reference
       Region 2h7d A 309-405 order
Seq 820-844 Hetero dimer : P12003
 Evidence X-RAY 1zvz B Reference
       Region 1zvz B 820-820 disorder
       Region 1zvz B 821-842 order
       Region 1zvz B 843-844 disorder
Seq 849-879 Hetero dimer : P12003
 Evidence X-RAY 1u6h B Reference
       Region 1u6h B 849-852 disorder
       Region 1u6h B 853-876 order
       Region 1u6h B 877-879 disorder
Seq 1944-1969 Hetero dimer : P12003
 Evidence X-RAY 1xwj B Reference
       Region 1xwj B 1944-1945 disorder
       Region 1xwj B 1946-1969 order
Seq 1944-1969 Hetero dimer : P18206
 Evidence X-RAY 1rkc B Reference
       Region 1rkc B 1944-1969 order
Seq 2344-2368 Hetero dimer : P12003
 Evidence X-RAY 1zw2 B Reference
       Region 1zw2 B 2344-2364 order
       Region 1zw2 B 2365-2368 disorder
SeqProS possible 316-326,400-405 Same region of mouse homolog (P26039, 89%identity) is disordered in the free state. Hetero dimer : IID50194Complex
       Region 2h7e A 309-405 order
       Region 2h7d A 309-405 order
 
Prediction
NeProc
Disorder 138-160,409-489,565-580,630-636,657-662,688-698,715-730,788-793,843-848,937-946,1104-1111,1227-1237,1244-1250,1405-1417,1450-1458,1546-1552,1841-1842,1869-1877,2025-2046,2096-2106,2288-2304,2328-2336,2367-2376,2479-2491,2527-2541
Order 1-136,161-408,490-564,581-629,637-656,663-687,699-714,731-787,794-842,849-936,947-1103,1112-1226,1238-1243,1251-1287,1294-1404,1418-1449,1459-1481,1489-1545,1553-1748,1754-1840,1847-1868,1878-2024,2047-2095,2107-2287,2305-2327,2337-2366,2381-2478,2492-2526
ProS 138-160,409-413,428-435,440-489,565-580,636-636,688-692,715-730,937-946,1104-1111,1233-1237,1244-1250,1405-1417,1455-1458,1546-1552,1841-1842,1869-1877,2025-2046,2096-2106,2295-2304,2332-2336,2367-2376,2486-2491,2527-2541
AlphaFold
Disorder 1-3,38-44,55-58,93-95,120-125,132-172,196-211,227-227,268-269,272-274,320-325,375-376,397-487,518-521,523-523,600-603,659-659,787-800,816-817,843-853,855-855,881-881,904-910,912-912,946-946,1043-1046,1203-1205,1223-1231,1292-1292,1294-1296,1323-1330,1332-1333,1336-1336,1352-1358,1378-1378,1380-1383,1454-1460,1462-1464,1483-1484,1513-1520,1523-1523,1548-1548,1576-1586,1690-1691,1821-1821,1838-1845,1970-1970,1972-1972,2006-2008,2102-2102,2137-2137,2162-2162,2167-2168,2172-2172,2225-2226,2290-2304,2325-2341,2373-2390,2412-2420,2443-2448,2475-2506,2526-2541
Order 4-37,45-54,59-92,96-119,126-131,173-195,212-226,228-267,270-271,275-319,326-374,377-396,488-517,522-522,524-599,604-658,660-786,801-815,818-842,854-854,856-880,882-903,911-911,913-945,947-1042,1047-1202,1206-1222,1232-1291,1293-1293,1297-1322,1331-1331,1334-1335,1337-1351,1359-1377,1379-1379,1384-1453,1461-1461,1465-1482,1485-1512,1521-1522,1524-1547,1549-1575,1587-1689,1692-1820,1822-1837,1846-1969,1971-1971,1973-2005,2009-2101,2103-2136,2138-2161,2163-2166,2169-2171,2173-2224,2227-2289,2305-2324,2342-2372,2391-2411,2421-2442,2449-2474,2507-2525
Pfam Hmmer
PF00373 121-313 1.1e-98
PF01608 2340-2531 4.9e-103
SEG 401-406 ,671-690 ,766-777 ,866-879 ,884-895 ,919-950 ,1026-1040 ,1302-1323 ,1676-1687 ,1816-1827 ,2095-2105 ,2304-2326 ,2347-2365 ,2504-2521
Function
Function in SwissProt
Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.