Search Keyword:


Search option:


IID50218
 UniprotP63073
ProteinEukaryotic translation initiation factor 4E
GeneEif4e
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
217
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-217 Hetero dimer : IID00170Complex
 Evidence X-RAY 5bxv C Reference
       Region 5bxv C 27-32 disorder
       Region 5bxv C 33-205 order
       Region 5bxv C 206-209 disorder
       Region 5bxv C 210-217 order
 Evidence X-RAY 5bxv A Reference
       Region 5bxv A 27-32 disorder
       Region 5bxv A 33-206 order
       Region 5bxv A 207-217 disorder
Seq 28-217 Monomer :
 Evidence X-RAY 5m84 B Reference
       Region 5m84 B 28-30 disorder
       Region 5m84 B 31-188 order
       Region 5m84 B 189-191 disorder
       Region 5m84 B 192-204 order
       Region 5m84 B 205-211 disorder
       Region 5m84 B 212-217 order
 Evidence X-RAY 5m84 A Reference
       Region 5m84 A 28-30 disorder
       Region 5m84 A 31-204 order
       Region 5m84 A 205-211 disorder
       Region 5m84 A 212-217 order
 Evidence X-RAY 5m83 B Reference
       Region 5m83 B 28-30 disorder
       Region 5m83 B 31-189 order
       Region 5m83 B 190-191 disorder
       Region 5m83 B 192-203 order
       Region 5m83 B 204-217 disorder
 Evidence X-RAY 5m83 A Reference
       Region 5m83 A 28-30 disorder
       Region 5m83 A 31-205 order
       Region 5m83 A 206-211 disorder
       Region 5m83 A 212-217 order
 Evidence X-RAY 5m81 D Reference
       Region 5m81 D 28-31 disorder
       Region 5m81 D 32-200 order
       Region 5m81 D 201-211 disorder
       Region 5m81 D 212-217 order
 Evidence X-RAY 5m81 C Reference
       Region 5m81 C 28-31 disorder
       Region 5m81 C 32-203 order
       Region 5m81 C 204-211 disorder
       Region 5m81 C 212-217 order
 Evidence X-RAY 5m81 B Reference
       Region 5m81 B 28-205 order
       Region 5m81 B 206-207 disorder
       Region 5m81 B 208-217 order
 Evidence X-RAY 5m81 A Reference
       Region 5m81 A 28-28 disorder
       Region 5m81 A 29-206 order
       Region 5m81 A 207-208 disorder
       Region 5m81 A 209-217 order
 Evidence X-RAY 5m80 D Reference
       Region 5m80 D 28-30 disorder
       Region 5m80 D 31-188 order
       Region 5m80 D 189-217 disorder
 Evidence X-RAY 5m80 B Reference
       Region 5m80 B 28-30 disorder
       Region 5m80 B 31-205 order
       Region 5m80 B 206-211 disorder
       Region 5m80 B 212-217 order
 Evidence X-RAY 5m80 C Reference
       Region 5m80 C 28-30 disorder
       Region 5m80 C 31-189 order
       Region 5m80 C 190-196 disorder
       Region 5m80 C 197-201 order
       Region 5m80 C 202-217 disorder
 Evidence X-RAY 5m80 A Reference
       Region 5m80 A 28-30 disorder
       Region 5m80 A 31-204 order
       Region 5m80 A 205-211 disorder
       Region 5m80 A 212-217 order
 Evidence X-RAY 5m7z D Reference
       Region 5m7z D 28-32 disorder
       Region 5m7z D 33-178 order
       Region 5m7z D 179-180 disorder
       Region 5m7z D 181-190 order
       Region 5m7z D 191-217 disorder
 Evidence X-RAY 5m7z C Reference
       Region 5m7z C 28-31 disorder
       Region 5m7z C 32-101 order
       Region 5m7z C 102-113 disorder
       Region 5m7z C 114-167 order
       Region 5m7z C 168-171 disorder
       Region 5m7z C 172-178 order
       Region 5m7z C 179-181 disorder
       Region 5m7z C 182-191 order
       Region 5m7z C 192-217 disorder
 Evidence X-RAY 5m7z B Reference
       Region 5m7z B 28-31 disorder
       Region 5m7z B 32-205 order
       Region 5m7z B 206-211 disorder
       Region 5m7z B 212-217 order
 Evidence X-RAY 5m7z A Reference
       Region 5m7z A 28-30 disorder
       Region 5m7z A 31-205 order
       Region 5m7z A 206-211 disorder
       Region 5m7z A 212-217 order
 Evidence X-RAY 5m7x D Reference
       Region 5m7x D 28-30 disorder
       Region 5m7x D 31-199 order
       Region 5m7x D 200-211 disorder
       Region 5m7x D 212-217 order
 Evidence X-RAY 5m7x C Reference
       Region 5m7x C 28-30 disorder
       Region 5m7x C 31-50 order
       Region 5m7x C 51-53 disorder
       Region 5m7x C 54-107 order
       Region 5m7x C 108-111 disorder
       Region 5m7x C 112-168 order
       Region 5m7x C 169-170 disorder
       Region 5m7x C 171-190 order
       Region 5m7x C 191-211 disorder
       Region 5m7x C 212-217 order
 Evidence X-RAY 5m7x B Reference
       Region 5m7x B 28-29 disorder
       Region 5m7x B 30-205 order
       Region 5m7x B 206-211 disorder
       Region 5m7x B 212-217 order
 Evidence X-RAY 5m7x A Reference
       Region 5m7x A 28-29 disorder
       Region 5m7x A 30-204 order
       Region 5m7x A 205-211 disorder
       Region 5m7x A 212-217 order
 Evidence X-RAY 5m7w D Reference
       Region 5m7w D 28-31 disorder
       Region 5m7w D 32-199 order
       Region 5m7w D 200-217 disorder
 Evidence X-RAY 5m7w C Reference
       Region 5m7w C 28-31 disorder
       Region 5m7w C 32-107 order
       Region 5m7w C 108-110 disorder
       Region 5m7w C 111-200 order
       Region 5m7w C 201-217 disorder
 Evidence X-RAY 5m7w B Reference
       Region 5m7w B 28-31 disorder
       Region 5m7w B 32-205 order
       Region 5m7w B 206-210 disorder
       Region 5m7w B 211-217 order
 Evidence X-RAY 5m7w A Reference
       Region 5m7w A 28-31 disorder
       Region 5m7w A 32-205 order
       Region 5m7w A 206-211 disorder
       Region 5m7w A 212-217 order
 Evidence X-RAY 5m7v D Reference
       Region 5m7v D 28-30 disorder
       Region 5m7v D 31-189 order
       Region 5m7v D 190-217 disorder
 Evidence X-RAY 5m7v C Reference
       Region 5m7v C 28-31 disorder
       Region 5m7v C 32-195 order
       Region 5m7v C 196-217 disorder
 Evidence X-RAY 5m7v B Reference
       Region 5m7v B 28-30 disorder
       Region 5m7v B 31-205 order
       Region 5m7v B 206-211 disorder
       Region 5m7v B 212-217 order
 Evidence X-RAY 5m7v A Reference
       Region 5m7v A 28-30 disorder
       Region 5m7v A 31-205 order
       Region 5m7v A 206-211 disorder
       Region 5m7v A 212-217 order
 Evidence X-RAY 1l8b B Reference
       Region 1l8b B 28-217 order
 Evidence X-RAY 1l8b A Reference
       Region 1l8b A 28-35 disorder
       Region 1l8b A 36-206 order
       Region 1l8b A 207-211 disorder
       Region 1l8b A 212-217 order
 Evidence X-RAY 5j5y D Reference
       Region 5j5y D 28-30 disorder
       Region 5j5y D 31-86 order
       Region 5j5y D 87-88 disorder
       Region 5j5y D 89-107 order
       Region 5j5y D 108-110 disorder
       Region 5j5y D 111-147 order
       Region 5j5y D 148-148 disorder
       Region 5j5y D 149-168 order
       Region 5j5y D 169-171 disorder
       Region 5j5y D 172-190 order
       Region 5j5y D 191-196 disorder
       Region 5j5y D 197-203 order
       Region 5j5y D 204-212 disorder
       Region 5j5y D 213-216 order
       Region 5j5y D 217-217 disorder
 Evidence X-RAY 5j5y C Reference
       Region 5j5y C 28-30 disorder
       Region 5j5y C 31-170 order
       Region 5j5y C 171-175 disorder
       Region 5j5y C 176-190 order
       Region 5j5y C 191-217 disorder
 Evidence X-RAY 5j5y B Reference
       Region 5j5y B 28-30 disorder
       Region 5j5y B 31-205 order
       Region 5j5y B 206-211 disorder
       Region 5j5y B 212-217 order
 Evidence X-RAY 5j5y A Reference
       Region 5j5y A 28-30 disorder
       Region 5j5y A 31-205 order
       Region 5j5y A 206-210 disorder
       Region 5j5y A 211-217 order
 Evidence X-RAY 5j5o D Reference
       Region 5j5o D 28-30 disorder
       Region 5j5o D 31-194 order
       Region 5j5o D 195-196 disorder
       Region 5j5o D 197-204 order
       Region 5j5o D 205-210 disorder
       Region 5j5o D 211-217 order
 Evidence X-RAY 5j5o C Reference
       Region 5j5o C 28-30 disorder
       Region 5j5o C 31-203 order
       Region 5j5o C 204-211 disorder
       Region 5j5o C 212-217 order
 Evidence X-RAY 5j5o B Reference
       Region 5j5o B 28-30 disorder
       Region 5j5o B 31-205 order
       Region 5j5o B 206-211 disorder
       Region 5j5o B 212-217 order
 Evidence X-RAY 5j5o A Reference
       Region 5j5o A 28-30 disorder
       Region 5j5o A 31-205 order
       Region 5j5o A 206-211 disorder
       Region 5j5o A 212-217 order
 Evidence X-RAY 1ej1 B Reference
       Region 1ej1 B 28-217 order
 Evidence X-RAY 1ej1 A Reference
       Region 1ej1 A 28-35 disorder
       Region 1ej1 A 36-207 order
       Region 1ej1 A 208-211 disorder
       Region 1ej1 A 212-217 order
Seq 28-217 Hetero dimer : IID00170Complex
 Evidence X-RAY 1ejh D Reference
       Region 1ejh D 28-34 disorder
       Region 1ejh D 35-118 order
       Region 1ejh D 119-123 disorder
       Region 1ejh D 124-203 order
       Region 1ejh D 204-212 disorder
       Region 1ejh D 213-217 order
 Evidence X-RAY 1ejh C Reference
       Region 1ejh C 28-30 disorder
       Region 1ejh C 31-205 order
       Region 1ejh C 206-211 disorder
       Region 1ejh C 212-217 order
 Evidence X-RAY 1ejh B Reference
       Region 1ejh B 28-31 disorder
       Region 1ejh B 32-205 order
       Region 1ejh B 206-211 disorder
       Region 1ejh B 212-217 order
 Evidence X-RAY 1ejh A Reference
       Region 1ejh A 28-31 disorder
       Region 1ejh A 32-205 order
       Region 1ejh A 206-211 disorder
       Region 1ejh A 212-217 order
 Evidence X-RAY 1ej4 A Reference
       Region 1ej4 A 28-31 disorder
       Region 1ej4 A 32-205 order
       Region 1ej4 A 206-212 disorder
       Region 1ej4 A 213-217 order
Seqphosphorylation
    209-209 Phosphoserine; by PKC and MKNK2
    22-22 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-32,208-212
Order 33-207,213-217
ProS 208-212
AlphaFold
Disorder 1-29
Order 30-217
Pfam Hmmer
PF01652 2-217 1.4e-135
SEG 3-23
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (By similarity). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:18805096, PubMed:25456498). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (PubMed:18805096). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (PubMed:25456498). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity).