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IID50220
 UniprotP97947
ProteinNuclear receptor subfamily 0 group B member 2
GeneNr0b2
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
260
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 16-26 Hetero dimer : IID50211Complex
 Evidence X-RAY 1zh7 D Reference
       Region 1zh7 D 16-26 order
 Evidence X-RAY 1zh7 C Reference
       Region 1zh7 C 16-26 order
Seq 17-28 Hetero dimer : IID50074Complex
 Evidence X-RAY 1yp0 B Reference
       Region 1yp0 B 17-28 order
Seq 115-131 Hetero dimer : IID00041Complex
 Evidence X-RAY 1zgy B Reference
       Region 1zgy B 115-117 disorder
       Region 1zgy B 118-129 order
       Region 1zgy B 130-131 disorder
 
Prediction
NeProc
Disorder 1-17,28-42,124-141
Order 18-27,43-123,146-260
ProS 7-17,28-33,124-128
AlphaFold
Disorder 1-24,27-41,43-43,117-119,121-123,125-142,208-213,260-260
Order 25-26,42-42,44-116,120-120,124-124,143-207,214-259
Pfam Hmmer
PF00104 63-256 3e-34
SEG 132-144
Function
Function in SwissProt
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).