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IID50223
 UniprotQ05471
ProteinHelicase SWR1
GeneSWR1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1514
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 340-410 Hetero trimer : P60011,P80428
 Evidence X-RAY 5i9e H Reference
       Region 5i9e H 340-349 disorder
       Region 5i9e H 350-393 order
       Region 5i9e H 394-410 disorder
 Evidence X-RAY 5i9e E Reference
       Region 5i9e E 340-349 disorder
       Region 5i9e E 350-390 order
       Region 5i9e E 391-410 disorder
Seq 590-639 Hetero dimer : IID50196Complex,IID50226Complex
 Evidence X-RAY 4m6b C Reference
       Region 4m6b C 590-598 disorder
       Region 4m6b C 599-606 order
       Region 4m6b C 607-614 disorder
       Region 4m6b C 615-629 order
       Region 4m6b C 630-639 disorder
Seq 590-639 Hetero dimer : IID50196Complex,IID50226Complex
 Evidence X-RAY 4m6b F Reference
       Region 4m6b F 590-598 disorder
       Region 4m6b F 599-606 order
       Region 4m6b F 607-614 disorder
       Region 4m6b F 615-629 order
       Region 4m6b F 630-639 disorder
Seqdisorder 590-651
 Evidence NMR Reference
       Region 590-651 disorder
SeqProS verified 599-606,615-629 Hetero dimer : IID50196Complex,IID50226Complex
       Region 4m6b C 599-606 order
       Region 4m6b C 615-629 order
       Region 590-651 disorder
SeqProS verified 599-606,615-629 Hetero dimer : IID50196Complex,IID50226Complex
       Region 4m6b F 599-606 order
       Region 4m6b F 615-629 order
       Region 590-651 disorder
 
Prediction
NeProc
Disorder 1-13,66-269,316-339,458-682,1096-1097,1421-1435,1445-1496
Order 14-65,270-315,348-457,683-1095,1098-1420,1441-1444,1497-1514
ProS 66-71,243-249,254-269,332-339,458-474,520-527,532-541,604-608,1096-1097,1432-1435,1445-1475
AlphaFold
Disorder 1-17,33-33,35-120,135-265,269-269,276-283,316-316,318-318,320-350,454-455,457-685,872-887,893-911,914-914,1029-1039,1047-1047,1086-1098,1144-1164,1199-1205,1220-1220,1324-1327,1397-1397,1399-1504,1511-1514
Order 18-32,34-34,121-134,266-268,270-275,284-315,317-317,319-319,351-453,456-456,686-871,888-892,912-913,915-1028,1040-1046,1048-1085,1099-1143,1165-1198,1206-1219,1221-1323,1328-1396,1398-1398,1505-1510
Pfam Hmmer
PF07529 340-411 5.9e-24
PF00176 699-999 2e-115
PF00271 1281-1359 4.9e-24
SEG 83-106 ,232-245 ,394-404 ,481-511 ,561-595 ,609-623 ,681-692 ,1247-1259 ,1474-1495
Function
Function in SwissProt
Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Biological Process
Diagram with PDB data
SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer