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IID50224
 UniprotQ06208
ProteinProtein RIF2
GeneRIF2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
395
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-395 Hetero hexamer : IID50071Complex
 Evidence X-RAY 4bj5 F Reference
       Region 4bj5 F 36-48 order
 Evidence X-RAY 4bj5 D Reference
       Region 4bj5 D 36-48 order
 Evidence X-RAY 4bj5 B Reference
       Region 4bj5 B 1-62 disorder
       Region 4bj5 B 63-151 order
       Region 4bj5 B 152-187 disorder
       Region 4bj5 B 188-389 order
       Region 4bj5 B 390-395 disorder
 Evidence X-RAY 4bj5 A Reference
       Region 4bj5 A 1-60 disorder
       Region 4bj5 A 61-151 order
       Region 4bj5 A 152-187 disorder
       Region 4bj5 A 188-388 order
       Region 4bj5 A 389-395 disorder
Seq 35-395 Hetero trimer : IID50071Complex
 Evidence X-RAY 4bj6 F Reference
       Region 4bj6 F 36-48 order
 Evidence X-RAY 4bj6 D Reference
       Region 4bj6 D 36-48 order
 Evidence X-RAY 4bj6 A Reference
       Region 4bj6 A 35-59 disorder
       Region 4bj6 A 60-151 order
       Region 4bj6 A 152-187 disorder
       Region 4bj6 A 188-388 order
       Region 4bj6 A 389-395 disorder
 Evidence X-RAY 4bj6 B Reference
       Region 4bj6 B 35-62 disorder
       Region 4bj6 B 63-151 order
       Region 4bj6 B 152-187 disorder
       Region 4bj6 B 188-388 order
       Region 4bj6 B 389-395 disorder
Seq 65-380 Homo dimer :
 Evidence X-RAY 4bj1 A Reference
       Region 4bj1 A 65-67 disorder
       Region 4bj1 A 68-151 order
       Region 4bj1 A 152-186 disorder
       Region 4bj1 A 187-217 order
       Region 4bj1 A 218-223 disorder
       Region 4bj1 A 224-254 order
       Region 4bj1 A 255-258 disorder
       Region 4bj1 A 259-373 order
       Region 4bj1 A 374-380 disorder
 
Prediction
NeProc
Disorder 1-6,52-58
Order 7-51,59-395
ProS 1-6,52-58
AlphaFold
Disorder 1-62,151-187,219-222,387-395
Order 63-150,188-218,223-386
SEG 14-25 ,45-63 ,249-275
Function
Function in SwissProt
Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.