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IID50225
 UniprotQ07794
ProteinHistone acetyltransferase RTT109
GeneRTT109
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
436
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-127,171-403 Monomer :
 Evidence X-RAY 3cz7 A Reference
       Region 3cz7 A 1-127 order
       Region 3cz7 A 171-403 order
Seq 1-436 Hetero hexamer : IID50143Complex,IID50212Complex
 Evidence X-RAY 3q33 A Reference
       Region 3q33 A 1-129 order
       Region 3q33 A 130-133 disorder
       Region 3q33 A 134-165 order
       Region 3q33 A 166-171 disorder
       Region 3q33 A 172-404 order
       Region 3q33 A 405-436 disorder
Seq 1-436 Monomer :
 Evidence X-RAY 2zfn A Reference
       Region 2zfn A 1-142 order
       Region 2zfn A 143-174 disorder
       Region 2zfn A 175-404 order
       Region 2zfn A 405-436 disorder
 Evidence X-RAY 2rim A Reference
       Region 2rim A 1-142 order
       Region 2rim A 143-174 disorder
       Region 2rim A 175-404 order
       Region 2rim A 405-436 disorder
 Evidence X-RAY 3qm0 A Reference
       Region 3qm0 A 1-129 order
       Region 3qm0 A 180-404 order
       Region 3qm0 A 405-436 disorder
Seq 1-436 Hetero tetramer : IID50212Complex
 Evidence X-RAY 3q35 A Reference
       Region 3q35 A 1-129 order
       Region 3q35 A 130-133 disorder
       Region 3q35 A 134-165 order
       Region 3q35 A 166-171 disorder
       Region 3q35 A 172-404 order
       Region 3q35 A 405-436 disorder
Seq 1-436 Hetero trimer : IID50212Complex
 Evidence X-RAY 3q68 C Reference
       Region 3q68 C 1-403 order
       Region 3q68 C 404-436 disorder
 Evidence X-RAY 3q66 C Reference
       Region 3q66 C 1-426 order
       Region 3q66 C 427-436 disorder
SeqProS verified 144-155 Hetero trimer : IID50212Complex
       Region 3q66 C 1-426 order
       Region 2rim A 143-174 disorder
SeqProS verified 144-155 Hetero hexamer : IID50143Complex,IID50212Complex
       Region 3q33 A 134-165 order
       Region 2rim A 143-174 disorder
Seqacetylation
    290-290 N6-acetyllysine; by autocatalysis
 
Prediction
NeProc
Disorder 338-351,401-436
Order 1-37,42-124,135-140,145-177,184-337,356-400
AlphaFold
Disorder 161-172,322-323,405-436
Order 1-160,173-321,324-404
SEG 424-435
Function
Function in SwissProt
Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition.