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IID50229
 UniprotQ61391
ProteinNeprilysin
GeneMme
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
750
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-23 Hetero dimer : IID50114Complex
 Evidence X-RAY 2yvc D Reference
       Region 2yvc D 2-7 disorder
       Region 2yvc D 8-14 order
       Region 2yvc D 15-23 disorder
 Evidence X-RAY 2yvc E Reference
       Region 2yvc E 2-7 disorder
       Region 2yvc E 8-12 order
       Region 2yvc E 13-23 disorder
Seq 2-23 Hetero dimer : IID50114Complex
 Evidence X-RAY 2yvc F Reference
       Region 2yvc F 2-6 disorder
       Region 2yvc F 7-23 order
SeqProS predicted 8-14 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID50114Complex
       Region 2yvc D 8-14 order
       Region 2yvc E 8-12 order
SeqProS predicted 8-14 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID50114Complex
       Region 2yvc F 7-23 order
Seqphosphorylation
    6-6 Phosphoserine
    4-4 Phosphoserine
 
Prediction
NeProc
Disorder 1-28,52-57
Order 29-51,58-750
ProS 1-28,52-57
AlphaFold
Disorder 1-24
Order 25-750
Pfam Hmmer
PF05649 78-483 7.2e-92
PF01431 543-749 7.3e-74
SEG 29-48 ,463-478 ,489-507 ,515-526
Function
Function in SwissProt
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).