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IID50230
 UniprotQ62227
ProteinNuclear receptor subfamily 0 group B member 2
GeneNr0b2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
260
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 17-30 Hetero dimer : IID50074Complex
 Evidence X-RAY 1ymt B Reference
       Region 1ymt B 17-26 order
       Region 1ymt B 27-30 disorder
Seq 53-260 Hetero dimer : IID50234Complex,IID90020Complex
 Evidence X-RAY 4nuf A Reference
       Region 4nuf A 53-54 disorder
       Region 4nuf A 55-115 order
       Region 4nuf A 116-142 disorder
       Region 4nuf A 143-260 order
 
Prediction
NeProc
Disorder 1-17,28-42,121-142
Order 18-27,43-114,147-260
ProS 7-17,28-32,121-127
AlphaFold
Disorder 1-19,21-23,26-45,117-119,121-123,126-141,209-213,260-260
Order 20-20,24-25,46-116,120-120,124-125,142-208,214-259
Pfam Hmmer
PF00104 63-256 3.3e-32
Function
Function in SwissProt
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:8650544). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:8650544). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (PubMed:25212631). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (PubMed:30555544). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (PubMed:30555544).