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IID50231
 UniprotQ6PFX9
ProteinTankyrase-1
GeneTnks
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1320
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 308-655 Hetero tetramer : IID00155Complex
 Evidence X-RAY 5hkp B Reference
       Region 5hkp B 308-323 disorder
       Region 5hkp B 324-634 order
       Region 5hkp B 635-655 disorder
 Evidence X-RAY 5hkp A Reference
       Region 5hkp A 308-321 disorder
       Region 5hkp A 322-634 order
       Region 5hkp A 635-655 disorder
Seq 308-655 Hetero trimer : IID50192Complex
 Evidence X-RAY 3utm B Reference
       Region 3utm B 308-327 disorder
       Region 3utm B 328-634 order
       Region 3utm B 635-655 disorder
 Evidence X-RAY 3utm A Reference
       Region 3utm A 308-315 disorder
       Region 3utm A 316-635 order
       Region 3utm A 636-655 disorder
Seq 1097-1307 Monomer :
 Evidence X-RAY 4n4t B Reference
       Region 4n4t B 1097-1197 order
       Region 4n4t B 1198-1200 disorder
       Region 4n4t B 1201-1257 order
       Region 4n4t B 1258-1259 disorder
       Region 4n4t B 1260-1273 order
       Region 4n4t B 1274-1281 disorder
       Region 4n4t B 1282-1307 order
 Evidence X-RAY 4n4t A Reference
       Region 4n4t A 1097-1307 order
 
Prediction
NeProc
Disorder 1-155,966-1009,1307-1320
Order 156-965,1010-1306
ProS 74-88,110-125,132-155,966-971,985-995,1004-1009
AlphaFold
Disorder 1-173,633-641,955-1021,1048-1048,1052-1052,1078-1098,1121-1134,1176-1182,1184-1184,1190-1235,1249-1291,1306-1320
Order 174-632,642-954,1022-1047,1049-1051,1053-1077,1099-1120,1135-1175,1183-1183,1185-1189,1236-1248,1292-1305
Pfam Hmmer
PF00023 208-240 6.3e-07
PF00023 241-273 3.5e-10
PF00023 274-306 7.4e-09
PF00023 361-393 2.3e-10
PF00023 394-426 5.1e-08
PF00023 427-459 2.8e-09
PF00023 514-549 5.8e-06
PF00023 550-582 6.5e-07
PF00023 583-615 1e-06
PF00023 676-708 1.6e-09
PF00023 709-741 7.2e-08
PF00023 742-774 5.2e-09
PF00023 829-861 2.9e-12
PF00023 862-894 2.7e-06
PF00023 895-927 5.9e-07
PF07647 1017-1082 4.9e-17
PF00644 1098-1303 2.7e-18
SEG 8-17 ,20-55 ,68-86 ,91-175 ,792-810 ,996-1010 ,1164-1172
Function
Function in SwissProt
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.