Search Keyword:


Search option:


IID50237
 UniprotQ9Z200
ProteinSH2B adapter protein 2
GeneSh2b2
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
621
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 401-510 Homo dimer :
 Evidence X-RAY 1rpy B Reference
       Region 1rpy B 401-403 disorder
       Region 1rpy B 404-462 order
       Region 1rpy B 463-466 disorder
       Region 1rpy B 467-493 order
       Region 1rpy B 494-510 disorder
 Evidence X-RAY 1rpy A Reference
       Region 1rpy A 401-402 disorder
       Region 1rpy A 403-461 order
       Region 1rpy A 462-465 disorder
       Region 1rpy A 466-488 order
       Region 1rpy A 489-510 disorder
Seq 401-510 Hetero hexamer : P06213
 Evidence X-RAY 1rqq D Reference
       Region 1rqq D 401-401 disorder
       Region 1rqq D 402-464 order
       Region 1rqq D 465-466 disorder
       Region 1rqq D 467-486 order
       Region 1rqq D 487-510 disorder
 Evidence X-RAY 1rqq C Reference
       Region 1rqq C 401-401 disorder
       Region 1rqq C 402-464 order
       Region 1rqq C 465-466 disorder
       Region 1rqq C 467-486 order
       Region 1rqq C 487-510 disorder
Seq 609-621 Hetero dimer : IID00300Complex
 Evidence X-RAY 1yvh B Reference
       Region 1yvh B 609-611 disorder
       Region 1yvh B 612-620 order
       Region 1yvh B 621-621 disorder
Seqphosphorylation
    618-618 Phosphotyrosine
    597-597 Phosphoserine
    303-303 Phosphoserine
    130-130 Phosphoserine
    47-47 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-15,80-183,204-207,302-410,508-621
Order 16-79,184-199,208-301,411-507
ProS 80-87,102-115,123-144,160-176,302-315,321-336,347-374,388-392,401-410,508-513,528-532,610-621
AlphaFold
Disorder 1-13,15-15,77-185,200-209,222-225,299-364,375-402,495-499,511-621
Order 14-14,16-76,186-199,210-221,226-298,365-374,403-494,500-510
Pfam Hmmer
PF00169 187-299 2.8e-13
PF00017 409-486 2.2e-08
SEG 4-16 ,169-180 ,388-404 ,509-525 ,548-570
Function
Function in SwissProt
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis (By similarity). Involved in stimulation of glucose uptake by insulin. Involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Induces cytoskeletal reorganization and neurite outgrowth in cultured neurons.