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IID50239
 UniprotO43070
ProteinDNA repair and telomere maintenance protein nbs1
Genenbs1
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
613
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-321 Hetero tetramer : IID50240Complex
 Evidence X-RAY 3huf C Reference
       Region 3huf C 1-191 order
       Region 3huf C 192-195 disorder
       Region 3huf C 196-275 order
       Region 3huf C 276-283 disorder
       Region 3huf C 284-321 order
 Evidence X-RAY 3huf B Reference
       Region 3huf B 1-156 order
       Region 3huf B 157-158 disorder
       Region 3huf B 159-256 order
       Region 3huf B 257-258 disorder
       Region 3huf B 259-277 order
       Region 3huf B 278-283 disorder
       Region 3huf B 284-321 order
 Evidence X-RAY 3huf A Reference
       Region 3huf A 1-255 order
       Region 3huf A 256-261 disorder
       Region 3huf A 262-274 order
       Region 3huf A 275-287 disorder
       Region 3huf A 288-320 order
       Region 3huf A 321-321 disorder
Seq 1-330 Monomer :
 Evidence X-RAY 3i0n B Reference
       Region 3i0n B 1-319 order
       Region 3i0n B 320-324 disorder
 Evidence X-RAY 3i0n A Reference
       Region 3i0n A 1-320 order
       Region 3i0n A 321-324 disorder
 Evidence X-RAY 3i0m A Reference
       Region 3i0m A 1-319 order
       Region 3i0m A 320-324 disorder
 Evidence X-RAY 3hue A Reference
       Region 3hue A 1-155 order
       Region 3hue A 156-157 disorder
       Region 3hue A 158-274 order
       Region 3hue A 275-286 disorder
       Region 3hue A 287-321 order
       Region 3hue A 322-330 disorder
Seq 474-531 Hetero dimer : IID50245Complex
 Evidence X-RAY 4fbw C Reference
       Region 4fbw C 474-483 disorder
       Region 4fbw C 484-497 order
       Region 4fbw C 498-519 disorder
       Region 4fbw C 520-526 order
       Region 4fbw C 527-531 disorder
Seq 474-531 Monomer : IID50245Complex
 Evidence X-RAY 4fbq A Reference
       Region 4fbq A 474-476 disorder
       Region 4fbq A 477-497 order
       Region 4fbq A 498-517 disorder
       Region 4fbq A 518-526 order
       Region 4fbq A 527-531 disorder
 Evidence X-RAY 4fbq B Reference
       Region 4fbq B 474-479 disorder
       Region 4fbq B 480-496 order
       Region 4fbq B 497-531 disorder
Seq 474-531 Monomer : IID50245Complex
 Evidence X-RAY 4fbk A Reference
       Region 4fbk A 474-476 disorder
       Region 4fbk A 477-498 order
       Region 4fbk A 499-517 disorder
       Region 4fbk A 518-526 order
       Region 4fbk A 527-531 disorder
 Evidence X-RAY 4fbk B Reference
       Region 4fbk B 474-479 disorder
       Region 4fbk B 480-497 order
       Region 4fbk B 498-531 disorder
Seq 474-531 Hetero dimer : IID50245Complex
 Evidence X-RAY 4fbw D Reference
       Region 4fbw D 474-481 disorder
       Region 4fbw D 482-497 order
       Region 4fbw D 498-531 disorder
SeqProS possible 477-498 This region is described to be disordered in the free state (PubMed=19804755). Hetero dimer : IID50245Complex
       Region 4fbw D 482-497 order
SeqProS possible 477-498,518-526 This region is described to be disordered in the free state (PubMed=19804755). Hetero dimer : IID50245Complex
       Region 4fbw C 484-497 order
       Region 4fbw C 520-526 order
SeqProS possible 477-498,518-526 This region is described to be disordered in the free state (PubMed=19804755). : IID50245Complex
       Region 4fbq A 477-497 order
       Region 4fbq B 480-496 order
       Region 4fbq A 518-526 order
SeqProS possible 477-498,518-526 This region is described to be disordered in the free state (PubMed=19804755). : IID50245Complex
       Region 4fbk A 477-498 order
       Region 4fbk B 480-497 order
       Region 4fbk A 518-526 order
Seqphosphorylation
    355-355 Phosphoserine
 
Prediction
NeProc
Disorder 313-613
Order 1-56,65-188,194-276,286-312
ProS 313-319,448-452,510-524,549-557,605-613
AlphaFold
Disorder 157-157,281-284,304-304,317-317,319-516,518-518,520-613
Order 1-156,158-280,285-303,305-316,318-318,517-517,519-519
Pfam Hmmer
PF00498 23-103 9.4e-11
SEG 237-247 ,405-419 ,519-532 ,574-592
Function
Function in SwissProt
Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.
Biological Process
Diagram with PDB data
nbs1/rad32Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site