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IID50240
 UniprotO74986
ProteinDNA endonuclease ctp1
Genectp1
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
294
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-60 Homo tetramer :
 Evidence X-RAY 4x01 H Reference
       Region 4x01 H 5-9 disorder
       Region 4x01 H 10-57 order
       Region 4x01 H 58-60 disorder
 Evidence X-RAY 4x01 G Reference
       Region 4x01 G 5-8 disorder
       Region 4x01 G 9-52 order
       Region 4x01 G 53-60 disorder
 Evidence X-RAY 4x01 F Reference
       Region 4x01 F 5-8 disorder
       Region 4x01 F 9-55 order
       Region 4x01 F 56-60 disorder
 Evidence X-RAY 4x01 E Reference
       Region 4x01 E 5-8 disorder
       Region 4x01 E 9-54 order
       Region 4x01 E 55-60 disorder
 Evidence X-RAY 4x01 D Reference
       Region 4x01 D 5-8 disorder
       Region 4x01 D 9-56 order
       Region 4x01 D 57-60 disorder
 Evidence X-RAY 4x01 C Reference
       Region 4x01 C 5-8 disorder
       Region 4x01 C 9-58 order
       Region 4x01 C 59-60 disorder
 Evidence X-RAY 4x01 B Reference
       Region 4x01 B 5-9 disorder
       Region 4x01 B 10-58 order
       Region 4x01 B 59-60 disorder
 Evidence X-RAY 4x01 A Reference
       Region 4x01 A 5-8 disorder
       Region 4x01 A 9-57 order
       Region 4x01 A 58-60 disorder
Seq 72-84 Hetero tetramer : IID50239Complex
 Evidence X-RAY 3huf E Reference
       Region 3huf E 72-76 disorder
       Region 3huf E 77-81 order
       Region 3huf E 82-84 disorder
SeqProS predicted 77-81 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero tetramer : IID50239Complex
       Region 3huf E 77-81 order
Seqphosphorylation
    89-89 Phosphothreonine
    77-77 Phosphoserine
    78-78 Phosphothreonine
    79-79 Phosphothreonine
    87-87 Phosphoserine
    114-114 Phosphoserine
    165-165 Phosphoserine
 
Prediction
NeProc
Disorder 1-8,58-200,245-278
Order 9-57,201-244,279-294
ProS 85-93,110-113,118-121,152-169,177-200,245-251,256-278
AlphaFold
Disorder 1-2,63-154,161-161,163-163,171-224,237-279,290-294
Order 3-62,155-160,162-162,164-170,225-236,280-289
SEG 53-69
Function
Function in SwissProt
Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway.