IDEAL List

IDEAL

IID50247
UniprotP02699
ProteinRhodopsin
GeneRHO
OrganismBos taurus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

348

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 1-40 Monomer :

Evidence NMR 1edx A Reference

Region 1edx A 1-40 order

Seq 1-348 Hetero dimer : P0C7Q4

Evidence X-RAY 5en0 A Reference

Region 5en0 A 1-326 order

Region 5en0 A 327-348 disorder

Evidence X-RAY 4a4m A Reference

Region 4a4m A 1-326 order

Region 4a4m A 327-348 disorder

Seq 1-348 Hetero tetramer : P08168

Evidence X-RAY 4pxf A Reference

Region 4pxf A 1-1 disorder

Region 4pxf A 2-326 order

Region 4pxf A 327-348 disorder

Seq 1-348 Hetero dimer :

Evidence X-RAY 4x1h A Reference

Region 4x1h A 1-326 order

Region 4x1h A 327-348 disorder

Seq 1-348 Hetero dimer : P04695

Evidence X-RAY 4bey A Reference

Region 4bey A 1-326 order

Region 4bey A 327-348 disorder

Evidence X-RAY 3pqr A Reference

Region 3pqr A 1-326 order

Region 3pqr A 327-348 disorder

Evidence X-RAY 4j4q A Reference

Region 4j4q A 1-326 order

Region 4j4q A 327-348 disorder

Evidence X-RAY 3dqb A Reference

Region 3dqb A 1-326 order

Region 3dqb A 327-348 disorder

Seq 1-348 Monomer :

Evidence NMR 1ln6 A Reference

Region 1ln6 A 1-39 disorder

Region 1ln6 A 40-348 order

Evidence NMR 1jfp A Reference

Region 1jfp A 1-39 disorder

Region 1jfp A 40-348 order

Evidence X-RAY 4bez A Reference

Region 4bez A 1-326 order

Region 4bez A 327-348 disorder

Evidence X-RAY 1u19 B Reference

Region 1u19 B 1-348 order

Evidence X-RAY 1u19 A Reference

Region 1u19 A 1-348 order

Evidence X-RAY 5te5 A Reference

Region 5te5 A 1-348 order

Evidence X-RAY 5te3 A Reference

Region 5te3 A 1-326 order

Region 5te3 A 327-348 disorder

Evidence X-RAY 3oax B Reference

Region 3oax B 1-348 order

Evidence X-RAY 3oax A Reference

Region 3oax A 1-348 order

Evidence X-RAY 1l9h B Reference

Region 1l9h B 1-140 order

Region 1l9h B 141-148 disorder

Region 1l9h B 149-226 order

Region 1l9h B 227-243 disorder

Region 1l9h B 244-326 order

Region 1l9h B 327-348 disorder

Evidence X-RAY 1l9h A Reference

Region 1l9h A 1-235 order

Region 1l9h A 236-240 disorder

Region 1l9h A 241-330 order

Region 1l9h A 331-333 disorder

Region 1l9h A 334-348 order

Evidence X-RAY 2i37 C Reference

Region 2i37 C 1-121 order

Region 2i37 C 122-126 disorder

Region 2i37 C 127-230 order

Region 2i37 C 231-240 disorder

Region 2i37 C 241-333 order

Region 2i37 C 334-348 disorder

Evidence X-RAY 2i37 B Reference

Region 2i37 B 1-144 order

Region 2i37 B 145-149 disorder

Region 2i37 B 150-234 order

Region 2i37 B 235-237 disorder

Region 2i37 B 238-327 order

Region 2i37 B 328-348 disorder

Evidence X-RAY 2i37 A Reference

Region 2i37 A 1-229 order

Region 2i37 A 230-238 disorder

Region 2i37 A 239-310 order

Region 2i37 A 311-313 disorder

Region 2i37 A 314-329 order

Region 2i37 A 330-348 disorder

Evidence X-RAY 2i36 C Reference

Region 2i36 C 1-322 order

Region 2i36 C 323-348 disorder

Evidence X-RAY 2i36 B Reference

Region 2i36 B 1-136 order

Region 2i36 B 137-146 disorder

Region 2i36 B 147-324 order

Region 2i36 B 325-348 disorder

Evidence X-RAY 2i36 A Reference

Region 2i36 A 1-326 order

Region 2i36 A 327-348 disorder

Evidence X-RAY 2i35 A Reference

Region 2i35 A 1-326 order

Region 2i35 A 327-329 disorder

Region 2i35 A 330-331 order

Region 2i35 A 332-348 disorder

Evidence X-RAY 1hzx B Reference

Region 1hzx B 1-140 order

Region 1hzx B 141-148 disorder

Region 1hzx B 149-226 order

Region 1hzx B 227-243 disorder

Region 1hzx B 244-326 order

Region 1hzx B 327-348 disorder

Evidence X-RAY 1hzx A Reference

Region 1hzx A 1-235 order

Region 1hzx A 236-240 disorder

Region 1hzx A 241-330 order

Region 1hzx A 331-333 disorder

Region 1hzx A 334-348 order

Evidence X-RAY 1f88 B Reference

Region 1f88 B 1-142 order

Region 1f88 B 143-147 disorder

Region 1f88 B 148-226 order

Region 1f88 B 227-242 disorder

Region 1f88 B 243-326 order

Region 1f88 B 327-348 disorder

Evidence X-RAY 1f88 A Reference

Region 1f88 A 1-235 order

Region 1f88 A 236-239 disorder

Region 1f88 A 240-327 order

Region 1f88 A 328-333 disorder

Region 1f88 A 334-348 order

Evidence X-RAY 5dys A Reference

Region 5dys A 1-326 order

Region 5dys A 327-348 disorder

Evidence X-RAY 3c9m A Reference

Region 3c9m A 1-326 order

Region 3c9m A 327-348 disorder

Evidence X-RAY 3c9l A Reference

Region 3c9l A 1-326 order

Region 3c9l A 327-329 disorder

Region 3c9l A 330-331 order

Region 3c9l A 332-348 disorder

Seq 1-348 Homo dimer :

Evidence X-RAY 2j4y B Reference

Region 2j4y B 1-326 order

Region 2j4y B 327-348 disorder

Evidence X-RAY 2j4y A Reference

Region 2j4y A 1-326 order

Region 2j4y A 327-348 disorder

Evidence X-RAY 1gzm B Reference

Region 1gzm B 1-326 order

Region 1gzm B 327-329 disorder

Region 1gzm B 330-331 order

Region 1gzm B 332-348 disorder

Evidence X-RAY 1gzm A Reference

Region 1gzm A 1-326 order

Region 1gzm A 327-329 disorder

Region 1gzm A 330-331 order

Region 1gzm A 332-348 disorder

Evidence X-RAY 3pxo A Reference

Region 3pxo A 1-326 order

Region 3pxo A 327-348 disorder

Evidence X-RAY 2ped B Reference

Region 2ped B 1-348 order

Evidence X-RAY 2ped A Reference

Region 2ped A 1-348 order

Evidence X-RAY 2hpy B Reference

Region 2hpy B 1-348 order

Evidence X-RAY 2hpy A Reference

Region 2hpy A 1-348 order

Evidence X-RAY 2g87 B Reference

Region 2g87 B 1-348 order

Evidence X-RAY 2g87 A Reference

Region 2g87 A 1-348 order

Evidence X-RAY 3cap B Reference

Region 3cap B 1-326 order

Region 3cap B 327-348 disorder

Evidence X-RAY 3cap A Reference

Region 3cap A 1-326 order

Region 3cap A 327-348 disorder

Seq 1-348 Hetero dimer :

Evidence X-RAY 5wkt A Reference

Region 5wkt A 1-326 order

Region 5wkt A 327-348 disorder

Seq 1-348 Hetero tetramer : P04695

Evidence X-RAY 2x72 A Reference

Region 2x72 A 1-326 order

Region 2x72 A 327-348 disorder

Seq 93-123 Monomer :

Evidence NMR 1eds A Reference

Region 1eds A 93-123 order

Seq 172-205 Monomer :

Evidence NMR 1edv A Reference

Region 1edv A 172-205 order

Seq 268-293 Monomer :

Evidence NMR 1edw A Reference

Region 1edw A 268-293 order

Seq 291-315 Monomer :

Evidence NMR 1fdf A Reference

Region 1fdf A 291-315 order

Seqdisorder 330-348

Evidence NMR Reference

Region 330-348 disorder

Seq 330-348 Monomer :

Evidence NMR 1vqx A Reference

Region 1vqx A 330-348 order

Evidence NMR 1nzs A Reference

Region 1nzs A 330-348 order

SeqProS verified 330-348

This region is ordered when it is phosphorylated and binds upon arrestin. :

Region 1nzs A 330-348 order

Region 1vqx A 330-348 order

Region 330-348 disorder

Seqphosphorylation

343-343 Phosphoserine; by RK and GRK7

342-342 Phosphothreonine

340-340 Phosphothreonine

338-338 Phosphoserine

336-336 Phosphothreonine

335-335 Phosphothreonine

334-334 Phosphoserine

Seqacetylation

1-1 N-acetylmethionine

Prediction

NeProc

Disorder 1-5,238-242,327-348

Order 6-237,243-326

ProS 238-242,342-348

AlphaFold

Disorder 1-1,144-144,327-348

Order 2-143,145-326

Pfam Hmmer

PF00001 54-306 3.3e-61

SEG 231-247

Function

Function in SwissProt

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed:10926528, PubMed:12044163, PubMed:11972040, PubMed:16908857, PubMed:16586416, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:1396673, PubMed:15111114).

Biological Process

Diagram with PDB data
RHO/SAG	NMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state