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IID50249
 UniprotQ9WUI9
ProteinNuclear receptor coactivator 2
GeneNcoa2
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1465
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 686-698 Hetero dimer : IID00013Complex
 Evidence X-RAY 3l03 C Reference
       Region 3l03 C 686-686 disorder
       Region 3l03 C 687-697 order
       Region 3l03 C 698-698 disorder
 Evidence X-RAY 3l03 D Reference
       Region 3l03 D 686-687 disorder
       Region 3l03 D 688-696 order
       Region 3l03 D 697-698 disorder
Seq 686-698 Hetero tetramer : IID00013Complex
 Evidence X-RAY 3hlv C Reference
       Region 3hlv C 686-687 disorder
       Region 3hlv C 688-696 order
       Region 3hlv C 697-698 disorder
 Evidence X-RAY 3hlv D Reference
       Region 3hlv D 686-686 disorder
       Region 3hlv D 687-696 order
       Region 3hlv D 697-698 disorder
 Evidence X-RAY 3hm1 C Reference
       Region 3hm1 C 686-686 disorder
       Region 3hm1 C 687-696 order
       Region 3hm1 C 697-698 disorder
 Evidence X-RAY 3hm1 D Reference
       Region 3hm1 D 686-687 disorder
       Region 3hm1 D 688-696 order
       Region 3hm1 D 697-698 disorder
Seq 740-756 Hetero tetramer : IID00031Complex,IID50248Complex
 Evidence X-RAY 1xls I Reference
       Region 1xls I 740-754 order
       Region 1xls I 755-756 disorder
 Evidence X-RAY 1xls J Reference
       Region 1xls J 740-754 order
       Region 1xls J 755-756 disorder
 Evidence X-RAY 1xls K Reference
       Region 1xls K 740-754 order
       Region 1xls K 755-756 disorder
 Evidence X-RAY 1xls L Reference
       Region 1xls L 740-754 order
       Region 1xls L 755-756 disorder
 Evidence X-RAY 1xls M Reference
       Region 1xls M 740-756 order
 Evidence X-RAY 1xls N Reference
       Region 1xls N 740-756 order
 Evidence X-RAY 1xls O Reference
       Region 1xls O 740-756 order
 Evidence X-RAY 1xls P Reference
       Region 1xls P 740-756 order
SeqProS possible 690-694 LXXLL motif Hetero tetramer : IID00013Complex
       Region 3hlv C 688-696 order
       Region 3hlv D 687-696 order
SeqProS possible 690-694 LXXLL motif Hetero dimer : IID00013Complex
       Region 3l03 C 687-697 order
       Region 3l03 D 688-696 order
SeqProS possible 745-749 LXXLL motif Hetero tetramer : IID00031Complex,IID50248Complex
       Region 1xls I 740-754 order
       Region 1xls J 740-754 order
       Region 1xls K 740-754 order
       Region 1xls L 740-754 order
       Region 1xls M 740-756 order
       Region 1xls N 740-756 order
       Region 1xls O 740-756 order
       Region 1xls P 740-756 order
Seqphosphorylation
    499-499 Phosphoserine
    565-565 Phosphoserine
    29-29 Phosphoserine
    396-396 Phosphoserine
    487-487 Phosphoserine
    493-493 Phosphoserine
    554-554 Phosphoserine
    682-682 Phosphoserine
    699-699 Phosphoserine
    736-736 Phosphoserine
    771-771 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    636-636 N6-acetyllysine
    640-640 N6-acetyllysine
    780-780 N6-acetyllysine
    785-785 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-39,101-105,181-192,211-218,261-266,378-1439,1450-1465
Order 40-100,106-175,193-210,219-260,267-377,1440-1449
ProS 1-7,21-25,31-39,101-105,181-192,211-218,378-382,684-696,740-751,802-813,883-887,1084-1093,1427-1439,1450-1465
AlphaFold
Disorder 1-32,56-67,89-110,176-194,208-221,234-247,257-267,310-315,377-686,690-690,693-703,706-707,709-746,748-1076,1089-1089,1091-1093,1101-1190,1194-1194,1196-1232,1258-1465
Order 33-55,68-88,111-175,195-207,222-233,248-256,268-309,316-376,687-689,691-692,704-705,708-708,747-747,1077-1088,1090-1090,1094-1100,1191-1193,1195-1195,1233-1257
Pfam Hmmer
PF07469 1281-1338 8.7e-33
SEG 53-65 ,638-648 ,802-813 ,936-952 ,1021-1037 ,1183-1204 ,1245-1266 ,1292-1304 ,1379-1397 ,1411-1422
Function
Function in SwissProt
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.