Search Keyword:


Search option:


IID50251
 UniprotP34021
ProteinEcdysone receptor
GeneEcR
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
878
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 256-364 Hetero dimer : IID00031Complex
 Evidence X-RAY 1r0n B Reference
       Region 1r0n B 256-261 disorder
       Region 1r0n B 262-347 order
       Region 1r0n B 348-364 disorder
Seq 256-365 Hetero dimer : IID50250Complex
 Evidence X-RAY 1r0o B Reference
       Region 1r0o B 256-260 disorder
       Region 1r0o B 261-338 order
       Region 1r0o B 339-364 disorder
 Evidence X-RAY 2han B Reference
       Region 2han B 256-257 disorder
       Region 2han B 258-344 order
       Region 2han B 345-365 disorder
SeqProS verified 339-344 This region is ordered when it binds upon natural IR-1 element (DNA). Hetero dimer : IID50250Complex
       Region 2han B 258-344 order
       Region 1r0o B 339-364 disorder
 
Prediction
NeProc
Disorder 1-259,340-456,659-832,870-878
Order 260-339,457-654,833-869
ProS 1-20,40-72,79-86,91-101,125-132,145-149,160-164,229-233,340-348,377-385,415-443,772-778,788-803,827-832
AlphaFold
Disorder 1-260,356-378,393-396,448-448,451-451,522-524,654-657,684-878
Order 261-355,379-392,397-447,449-450,452-521,525-653,658-683
Pfam Hmmer
PF00105 262-337 7.3e-49
PF00104 468-649 9.2e-46
SEG 16-26 ,56-71 ,93-111 ,116-134 ,148-157 ,164-181 ,187-211 ,223-237 ,365-375 ,695-719 ,728-769 ,802-824 ,827-840
Function
Function in SwissProt
Receptor for ecdysone (PubMed:1913820, PubMed:30293839). Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839).