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IID50253
UniprotP51943
ProteinCyclin-A2
GeneCcna2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
422
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 163-422 Hetero tetramer : IID00034Complex
 Evidence X-RAY 3qhr B Reference
       Region 3qhr B 163-422 order
Seq 163-422 Hetero tetramer : IID00034Complex
 Evidence X-RAY 3qhw B Reference
       Region 3qhw B 163-422 order
Seq 163-422 Hetero tetramer : IID00034Complex
 Evidence X-RAY 3qhw D Reference
       Region 3qhw D 163-422 order
Seq 163-422 Hetero tetramer : IID00034Complex
 Evidence X-RAY 3qhr D Reference
       Region 3qhr D 163-422 order
Seq 165-422 Hetero dimer : IID00034Complex
 Evidence X-RAY 4ii5 D Reference
       Region 4ii5 D 165-421 order
       Region 4ii5 D 422-422 disorder
 Evidence X-RAY 4ii5 B Reference
       Region 4ii5 B 165-420 order
       Region 4ii5 B 421-422 disorder
 Evidence X-RAY 4i3z D Reference
       Region 4i3z D 165-421 order
 Evidence X-RAY 4i3z B Reference
       Region 4i3z B 165-421 order
Seqphosphorylation
    5-5 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-158,417-422
Order 159-416
ProS 18-27,40-50,57-63,71-79,91-97,119-125,133-138,148-158,417-422
AlphaFold
Disorder 1-164,422-422
Order 165-421
Pfam Hmmer
PF00134 171-297 2.4e-72
PF02984 299-421 1.1e-39
Function
Function in SwissProt
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.