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IID50261
 UniprotP48432
ProteinTranscription factor SOX-2
GeneSox2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
319
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 41-120 Hetero dimer : IID00144Complex
 Evidence X-RAY 1gt0 D Reference
       Region 1gt0 D 41-119 order
       Region 1gt0 D 120-120 disorder
SeqProS possible 105-115 Same region of human homolog (P48431, 95%identity) is disordered in the free state. Hetero dimer : IID00144Complex
       Region 1gt0 D 41-119 order
Seqphosphorylation
    253-253 Phosphoserine
 
Prediction
NeProc
Disorder 1-50,114-319
Order 51-113
ProS 1-11,40-50,150-167,267-282,312-319
AlphaFold
Disorder 1-40,122-272,276-276,279-319
Order 41-121,273-275,277-278
Pfam Hmmer
PF00505 43-111 1.1e-34
SEG 19-35 ,137-156 ,248-263
Function
Function in SwissProt
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Biological Process
Diagram with PDB data
Sox2/POU2F1/DNACrystal structure of a POU/HMG/DNA ternary complex