Search Keyword:


Search option:


IID50262
 UniprotQ8C147
ProteinDedicator of cytokinesis protein 8
GeneDock8
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2100
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1787-2067 Hetero dimer : IID00308Complex
 Evidence X-RAY 3vhl A Reference
       Region 3vhl A 1787-1791 disorder
       Region 3vhl A 1792-1879 order
       Region 3vhl A 1880-1888 disorder
       Region 3vhl A 1889-2064 order
       Region 3vhl A 2065-2067 disorder
Seqphosphorylation
    2088-2088 Phosphoserine
    1244-1244 Phosphoserine
    1146-1146 Phosphoserine
    937-937 Phosphoserine
    905-905 Phosphoserine
    452-452 Phosphoserine
    139-139 Phosphoserine
    20-20 Phosphoserine
 
Prediction
NeProc
Disorder 1-52,152-157,164-214,418-453,868-909,923-947,1117-1143,1238-1290,1351-1395,2075-2100
Order 53-151,158-163,215-417,454-765,772-862,911-922,953-1116,1144-1237,1291-1350,1396-2074
ProS 10-29,152-157,164-214,418-421,432-441,868-909,923-947,1140-1143,1238-1268,1284-1290,1351-1366,1382-1395,2075-2096
AlphaFold
Disorder 1-55,71-90,134-154,167-200,217-220,245-254,371-371,373-374,414-464,495-501,536-538,575-578,658-662,753-753,861-958,1004-1007,1039-1041,1113-1142,1234-1286,1344-1415,1450-1456,1561-1566,1610-1616,1637-1637,1705-1722,1787-1789,1984-1988,2002-2003,2064-2100
Order 56-70,91-133,155-166,201-216,221-244,255-370,372-372,375-413,465-494,502-535,539-574,579-657,663-752,754-860,959-1003,1008-1038,1042-1112,1143-1233,1287-1343,1416-1449,1457-1560,1567-1609,1617-1636,1638-1704,1723-1786,1790-1983,1989-2001,2004-2063
Pfam Hmmer
PF06920 1883-2062 6e-125
SEG 786-803 ,1003-1020 ,1123-1138 ,1236-1246 ,1371-1383
Function
Function in SwissProt
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (PubMed:22461490, PubMed:25713392). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (By similarity).