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IID50266
 UniprotO55000
ProteinSerine/threonine-protein phosphatase 1 regulatory subunit 10
GenePpp1r10
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
872
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 309-433
 Evidence NMR Reference
       Region 309-433 disorder
Seq 393-433 Hetero dimer : IID00311Complex
 Evidence X-RAY 4mp0 D Reference
       Region 4mp0 D 394-396 disorder
       Region 4mp0 D 397-424 order
       Region 4mp0 D 425-433 disorder
 Evidence X-RAY 4mp0 B Reference
       Region 4mp0 B 394-395 disorder
       Region 4mp0 B 396-425 order
       Region 4mp0 B 426-433 disorder
 Evidence X-RAY 4moy B Reference
       Region 4moy B 393-424 order
       Region 4moy B 425-433 disorder
SeqProS verified 396-424 Hetero dimer : IID00311Complex
       Region 4mp0 B 396-425 order
       Region 4mp0 D 397-424 order
       Region 4moy B 393-424 order
       Region 309-433 disorder
Seqphosphorylation
    313-313 Phosphoserine
    382-382 Phosphoserine
    398-398 Phosphothreonine; by PKA
    545-545 Phosphoserine
    591-591 Phosphoserine
 
Prediction
NeProc
Disorder 1-3,131-398,440-452,505-841
Order 4-130,399-439,453-504,842-872
ProS 131-143,278-295,388-392,440-452,516-524,553-559,623-635,646-658,675-690,695-841
AlphaFold
Disorder 1-3,149-397,417-418,420-428,451-452,495-512,514-514,517-555,557-601,603-605,609-609,611-717,719-837,869-872
Order 4-148,398-416,419-419,429-450,453-494,513-513,515-516,556-556,602-602,606-608,610-610,718-718,838-868
Pfam Hmmer
PF00642 839-865 5.2e-05
SEG 85-104 ,154-165 ,179-196 ,248-259 ,303-310 ,325-346 ,502-517 ,540-552 ,566-578 ,621-639 ,644-759 ,776-796 ,799-837
Function
Function in SwissProt
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.