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IID50267
UniprotO77059
ProteinCryptochrome-1
Genecry
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
542
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-539 Monomer :
 Evidence X-RAY 4gu5 B Reference
       Region 4gu5 B 1-1 disorder
       Region 4gu5 B 2-539 order
 Evidence X-RAY 4gu5 A Reference
       Region 4gu5 A 1-2 disorder
       Region 4gu5 A 3-539 order
Seq 1-542 Homo dimer :
 Evidence X-RAY 4k03 B Reference
       Region 4k03 B 1-537 order
       Region 4k03 B 538-542 disorder
 Evidence X-RAY 4k03 A Reference
       Region 4k03 A 1-3 disorder
       Region 4k03 A 4-213 order
       Region 4k03 A 214-218 disorder
       Region 4k03 A 219-537 order
       Region 4k03 A 538-542 disorder
 Evidence X-RAY 4jzy B Reference
       Region 4jzy B 1-293 order
       Region 4jzy B 299-540 order
 Evidence X-RAY 4jzy A Reference
       Region 4jzy A 1-1 disorder
       Region 4jzy A 2-293 order
       Region 4jzy A 299-540 order
 
Prediction
NeProc
Disorder 1-4,523-526
Order 5-181,187-294,302-522,527-542
ProS 523-526
AlphaFold
Disorder 1-2,292-302,540-542
Order 3-291,303-539
Pfam Hmmer
PF00875 5-186 1.8e-77
PF03441 224-513 2.2e-144
SEG 60-72
Function
Function in SwissProt
Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.