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IID50273
 UniprotP32790
ProteinActin cytoskeleton-regulatory complex protein SLA1
GeneSLA1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1244
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 191-202 Hetero dimer : P43603
 Evidence X-RAY 1ssh B Reference
       Region 1ssh B 191-191 disorder
       Region 1ssh B 192-202 order
Seq 350-420 Hetero dimer : P0CG63
 Evidence NMR 2jt4 A Reference
       Region 2jt4 A 350-420 order
       Region 2jt4 A 350-353 high_rmsd
       Region 2jt4 A 415-420 high_rmsd
Seq 357-413 Monomer :
 Evidence X-RAY 1z9z B Reference
       Region 1z9z B 357-413 order
 Evidence X-RAY 1z9z A Reference
       Region 1z9z A 357-413 order
 Evidence X-RAY 2v1q B Reference
       Region 2v1q B 357-413 order
 Evidence X-RAY 2v1q A Reference
       Region 2v1q A 357-413 order
Seq 495-560 Monomer :
 Evidence NMR 2hbp A Reference
       Region 2hbp A 495-560 order
       Region 2hbp A 495-495 high_rmsd
Seq 653-724 Monomer :
 Evidence X-RAY 3idw A Reference
       Region 3idw A 653-653 disorder
       Region 3idw A 654-719 order
       Region 3idw A 720-724 disorder
Seqphosphorylation
    447-447 Phosphoserine
    449-449 Phosphoserine
    454-454 Phosphoserine
    831-831 Phosphothreonine
    858-858 Phosphothreonine
    904-904 Phosphothreonine
    799-799 Phosphoserine
    887-887 Phosphothreonine
    984-984 Phosphothreonine
    993-993 Phosphothreonine
    996-996 Phosphoserine
    1075-1075 Phosphothreonine
 
Prediction
NeProc
Disorder 130-248,253-257,283-287,321-346,414-525,530-541,547-553,561-570,619-651,704-1244
Order 1-46,55-83,88-129,249-252,258-263,269-282,288-320,347-350,355-413,526-529,542-546,554-560,571-618,652-703
ProS 253-257,321-333,493-525,547-553,568-570,704-717,739-744,773-780,1117-1121,1217-1223,1229-1244
AlphaFold
Disorder 1-3,49-54,131-251,341-355,415-489,559-570,615-654,718-1230
Order 4-48,55-130,252-340,356-414,490-558,571-614,655-717,1231-1244
Pfam Hmmer
PF00018 6-68 2.7e-10
PF00018 72-130 4.9e-21
PF00018 356-413 1.5e-21
PF03983 486-555 1.2e-56
PF08226 1026-1104 5.7e-05
SEG 96-107 ,140-159 ,182-214 ,222-243 ,436-454 ,467-487 ,561-608 ,625-642 ,645-653 ,757-771 ,783-795 ,836-852 ,1205-1215
Function
Function in SwissProt
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.