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IID50275
 UniprotP38634
ProteinProtein SIC1
GeneSIC1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
284
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-90
 Evidence NMR Reference
       Region 1-90 disorder
Seq 46-61 Hetero tetramer : Q00684
 Evidence X-RAY 6g86 D Reference
       Region 6g86 D 46-51 disorder
       Region 6g86 D 52-61 order
 Evidence X-RAY 6g86 C Reference
       Region 6g86 C 46-50 disorder
       Region 6g86 C 51-61 order
Seq 67-85 Hetero trimer : P07834
 Evidence X-RAY 3v7d E Reference
       Region 3v7d E 67-70 disorder
       Region 3v7d E 71-80 order
       Region 3v7d E 81-85 disorder
SeqProS verified 51-61 Hetero tetramer : Q00684
       Region 6g86 C 51-61 order
       Region 6g86 D 52-61 order
       Region 1-90 disorder
SeqProS verified 71-80 Hetero trimer : P07834
       Region 3v7d E 71-80 order
       Region 1-90 disorder
Seqphosphorylation
    201-201 Phosphoserine
    173-173 Phosphothreonine
    198-198 Phosphoserine
    76-76 Phosphoserine
    33-33 Phosphothreonine
    5-5 Phosphothreonine; by PHO85
 
Prediction
NeProc
Disorder 1-188,197-208,280-284
Order 189-196,209-222,227-279
ProS 1-11,41-49,68-82,89-100,106-117,147-152,160-188,205-208,280-284
AlphaFold
Disorder 1-137,140-180,182-184,186-209,214-214,218-219,276-284
Order 138-139,181-181,185-185,210-213,215-217,220-275
SEG 129-135 ,202-209
Function
Function in SwissProt
Substrate and inhibitor of the cyclin-dependent protein kinase CDC28. Its activity could be important for faithful segregation of chromosomes to daughter cells. It acts in response to a signal from a post-start checkpoint.
Biological Process
Diagram with PDB data
SIC1/SKP1/CDC4Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
SIC1/CDC14Structure of Cdc14 bound to SIC1 PxL motif