IDEAL List

IDEAL

IID50279
UniprotP42230
ProteinSignal transducer and activator of transcription 5A
GeneStat5a
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

793

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 128-712 Homo dimer :

Evidence X-RAY 1y1u A Reference

Region 1y1u A 128-137 disorder

Region 1y1u A 138-423 order

Region 1y1u A 424-432 disorder

Region 1y1u A 433-690 order

Region 1y1u A 691-712 disorder

Evidence X-RAY 1y1u B Reference

Region 1y1u B 128-137 disorder

Region 1y1u B 138-423 order

Region 1y1u B 424-432 disorder

Region 1y1u B 433-690 order

Region 1y1u B 691-712 disorder

Evidence X-RAY 1y1u C Reference

Region 1y1u C 128-137 disorder

Region 1y1u C 138-423 order

Region 1y1u C 424-432 disorder

Region 1y1u C 433-690 order

Region 1y1u C 691-712 disorder

Seqphosphorylation

779-779 Phosphoserine

694-694 Phosphotyrosine

682-682 Phosphotyrosine

90-90 Phosphotyrosine

128-128 Phosphoserine

Prediction

NeProc

Disorder 128-138,190-210,421-434,701-793

Order 1-127,139-189,211-401,407-420,435-541,547-700

ProS 197-210,421-425,701-705,743-747,762-769,775-793

AlphaFold

Disorder 1-2,125-137,386-390,429-432,637-638,687-691,707-793

Order 3-124,138-385,391-428,433-636,639-686,692-706

Pfam Hmmer

PF02865 2-126 4.1e-76

PF01017 138-330 1.9e-93

PF02864 332-583 5.8e-166

PF00017 589-670 2.7e-13

SEG 234-248

Function

Function in SwissProt

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.