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IID50283
 UniprotP48598
ProteinEukaryotic translation initiation factor 4E1
GeneeIF4E1
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
259
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 19-259 Hetero dimer : IID50295Complex
 Evidence X-RAY 4axg B Reference
       Region 4axg B 19-79 disorder
       Region 4axg B 80-94 order
       Region 4axg B 95-102 disorder
       Region 4axg B 103-246 order
       Region 4axg B 247-251 disorder
       Region 4axg B 252-259 order
Seq 19-259 Hetero dimer : IID50295Complex
 Evidence X-RAY 4axg A Reference
       Region 4axg A 19-76 disorder
       Region 4axg A 77-249 order
       Region 4axg A 250-251 disorder
       Region 4axg A 252-259 order
Seq 80-259 Hetero dimer : Q9XZ56
 Evidence X-RAY 4ue8 A Reference
       Region 4ue8 A 80-94 order
       Region 4ue8 A 95-101 disorder
       Region 4ue8 A 102-245 order
       Region 4ue8 A 246-259 disorder
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4uea C Reference
       Region 4uea C 80-246 order
       Region 4uea C 247-259 disorder
Seq 80-259 Hetero trimer : O61380
 Evidence X-RAY 4uec A Reference
       Region 4uec A 80-247 order
       Region 4uec A 248-259 disorder
 Evidence X-RAY 4uec C Reference
       Region 4uec C 80-247 order
       Region 4uec C 248-259 disorder
Seq 80-259 Hetero dimer : O61380
 Evidence X-RAY 5t48 A Reference
       Region 5t48 A 80-249 order
       Region 5t48 A 250-251 disorder
       Region 5t48 A 252-259 order
Seq 80-259 Hetero dimer : O61380
 Evidence X-RAY 5t47 C Reference
       Region 5t47 C 80-232 order
       Region 5t47 C 233-234 disorder
       Region 5t47 C 235-244 order
       Region 5t47 C 245-254 disorder
       Region 5t47 C 255-259 order
 Evidence X-RAY 5t47 A Reference
       Region 5t47 A 80-96 order
       Region 5t47 A 97-100 disorder
       Region 5t47 A 101-244 order
       Region 5t47 A 245-252 disorder
       Region 5t47 A 253-259 order
Seq 80-259 Hetero dimer : Q9VR35
 Evidence X-RAY 5abv G Reference
       Region 5abv G 80-230 order
       Region 5abv G 231-232 disorder
       Region 5abv G 233-247 order
       Region 5abv G 248-251 disorder
       Region 5abv G 252-259 order
 Evidence X-RAY 5abv E Reference
       Region 5abv E 80-248 order
       Region 5abv E 249-251 disorder
       Region 5abv E 252-259 order
 Evidence X-RAY 5abv C Reference
       Region 5abv C 80-161 order
       Region 5abv C 162-163 disorder
       Region 5abv C 164-199 order
       Region 5abv C 200-201 disorder
       Region 5abv C 202-248 order
       Region 5abv C 249-252 disorder
       Region 5abv C 253-259 order
 Evidence X-RAY 5abv A Reference
       Region 5abv A 80-248 order
       Region 5abv A 249-251 disorder
       Region 5abv A 252-259 order
 Evidence X-RAY 5abu A Reference
       Region 5abu A 80-161 order
       Region 5abu A 162-164 disorder
       Region 5abu A 165-248 order
       Region 5abu A 249-252 disorder
       Region 5abu A 253-259 order
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4ueb E Reference
       Region 4ueb E 80-246 order
       Region 4ueb E 247-255 disorder
       Region 4ueb E 256-259 order
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4uea A Reference
       Region 4uea A 80-247 order
       Region 4uea A 248-259 disorder
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4ueb A Reference
       Region 4ueb A 80-229 order
       Region 4ueb A 230-235 disorder
       Region 4ueb A 236-245 order
       Region 4ueb A 246-259 disorder
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4uea E Reference
       Region 4uea E 80-245 order
       Region 4uea E 246-259 disorder
Seq 80-259 Hetero dimer :
 Evidence X-RAY 4ueb C Reference
       Region 4ueb C 80-246 order
       Region 4ueb C 247-259 disorder
Seq 80-259 Hetero dimer : Q8IH18
 Evidence X-RAY 4ue9 A Reference
       Region 4ue9 A 80-96 order
       Region 4ue9 A 97-98 disorder
       Region 4ue9 A 99-247 order
       Region 4ue9 A 248-251 disorder
       Region 4ue9 A 252-259 order
 
Prediction
NeProc
Disorder 1-76
Order 77-259
ProS 1-13
AlphaFold
Disorder 1-74,249-251
Order 75-248,252-259
Pfam Hmmer
PF01652 19-259 6.2e-134
SEG 30-42 ,53-72 ,168-180
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition (PubMed:28875934).