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IID50284
 UniprotP52912
ProteinNucleolysin TIA-1
GeneTia1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
386
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 87-92,104-199 Monomer :
 Evidence NMR 2rne A Reference
       Region 2rne A 87-89 high_rmsd
       Region 2rne A 87-92 order
       Region 2rne A 104-199 order
       Region 2rne A 174-188 high_rmsd
 Evidence NMR 2dgo A Reference
       Region 2dgo A 87-89 high_rmsd
       Region 2dgo A 87-92 order
       Region 2dgo A 104-199 order
       Region 2dgo A 174-188 high_rmsd
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-3,88-96,185-206,288-307,317-386
Order 4-83,103-184,207-287,308-316
ProS 201-206,303-307,317-346,352-356,375-386
AlphaFold
Disorder 1-3,41-44,83-104,184-199,287-386
Order 4-40,45-82,105-183,200-286
Pfam Hmmer
PF00076 9-78 5e-28
PF00076 108-179 3.6e-30
PF00076 216-281 2.2e-22
SEG 59-65 ,82-104
Function
Function in SwissProt
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity).