IDEAL List

IDEAL

IID50286
UniprotP97465
ProteinDocking protein 1
GeneDok1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

482

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 152-266 Hetero tetramer : IID50274Complex

Evidence X-RAY 1uef B Reference

Region 1uef B 152-254 order

Region 1uef B 255-266 disorder

Evidence X-RAY 1uef A Reference

Region 1uef A 152-255 order

Region 1uef A 256-266 disorder

Seq 152-266 Homo dimer :

Evidence X-RAY 1p5t B Reference

Region 1p5t B 152-255 order

Region 1p5t B 256-266 disorder

Evidence X-RAY 1p5t A Reference

Region 1p5t A 152-257 order

Region 1p5t A 258-266 disorder

Seqphosphorylation

408-408 Phosphotyrosine

415-415 Phosphoserine

450-450 Phosphotyrosine

397-397 Phosphotyrosine; by INSR

376-376 Phosphotyrosine

361-361 Phosphotyrosine

340-340 Phosphotyrosine

336-336 Phosphotyrosine

295-295 Phosphotyrosine

290-290 Phosphoserine

269-269 Phosphoserine

48-48 Phosphoserine

Seqacetylation

1-1 N-acetylmethionine

Prediction

NeProc

Disorder 14-26,123-147,250-482

Order 1-13,27-122,148-249

ProS 14-26,133-147,250-254,298-302,335-342,357-368,374-409,422-433,439-455,460-478

AlphaFold

Disorder 1-1,45-62,121-151,192-192,256-339,349-358,360-360,362-363,365-402,405-482

Order 2-44,63-120,152-191,193-255,340-348,359-359,361-361,364-364,403-404

Pfam Hmmer

PF00169 4-119 1.1e-09

PF02174 152-254 2.5e-53

SEG 47-59 ,71-84 ,247-262 ,411-424

Function

Function in SwissProt

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).