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IID50289
 UniprotQ06706
ProteinElongator complex protein 1
GeneIKI3
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1349
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 919-1349 Homo dimer :
 Evidence X-RAY 5cqs C Reference
       Region 5cqs C 919-1165 order
       Region 5cqs C 1166-1253 disorder
       Region 5cqs C 1254-1306 order
       Region 5cqs C 1307-1336 disorder
       Region 5cqs C 1337-1349 order
 Evidence X-RAY 5cqs B Reference
       Region 5cqs B 919-919 disorder
       Region 5cqs B 920-1172 order
       Region 5cqs B 1173-1252 disorder
       Region 5cqs B 1253-1309 order
       Region 5cqs B 1310-1336 disorder
       Region 5cqs B 1337-1349 order
 Evidence X-RAY 5cqs D Reference
       Region 5cqs D 919-1173 order
       Region 5cqs D 1174-1251 disorder
       Region 5cqs D 1252-1307 order
       Region 5cqs D 1308-1336 disorder
       Region 5cqs D 1337-1349 order
 Evidence X-RAY 5cqs A Reference
       Region 5cqs A 919-1171 order
       Region 5cqs A 1172-1251 disorder
       Region 5cqs A 1252-1310 order
       Region 5cqs A 1311-1336 disorder
       Region 5cqs A 1337-1349 order
Seqphosphorylation
    529-529 Phosphoserine
    539-539 Phosphoserine
    551-551 Phosphoserine
    636-636 Phosphoserine
    828-828 Phosphoserine
    1198-1198 Phosphoserine; by HRR25
    1202-1202 Phosphoserine; by HRR25
    1205-1205 Phosphoserine
    1209-1209 Phosphoserine
 
Prediction
NeProc
Disorder 1-26,32-41,211-222,836-847,1191-1244,1321-1326,1343-1349
Order 27-31,42-210,227-270,282-694,702-825,831-835,853-1190,1245-1314,1327-1342
ProS 1-26,836-842,1191-1197,1207-1227,1238-1244,1321-1326,1343-1349
AlphaFold
Disorder 1-17,35-43,189-238,274-274,325-328,627-638,822-826,1184-1184,1186-1242,1244-1244,1320-1326
Order 18-34,44-188,239-273,275-324,329-626,639-821,827-1183,1185-1185,1243-1243,1245-1319,1327-1349
SEG 264-276 ,1169-1181 ,1212-1248
Function
Function in SwissProt
Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (PubMed:10024884, PubMed:11296232, PubMed:11689709, PubMed:11904415). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:15769872, PubMed:18755837). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin) (PubMed:12424236). May also be involved in sensitivity to Pichia inositovora toxin. May be involved in tRNA modification (PubMed:13680368). Independently, ELP3 may be involved in polarized exocytosis (PubMed:15780940).