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IID50292
UniprotQ80VJ2
ProteinSteroid receptor RNA activator 1
GeneSra1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
232
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 102-206 Monomer :
 Evidence NMR 2yru A Reference
       Region 2yru A 102-206 order
       Region 2yru A 102-104 high_rmsd
Seqphosphorylation
    48-48 Phosphoserine
 
Prediction
NeProc
Disorder 1-92,192-220
Order 93-191
ProS 1-22,212-220
AlphaFold
Disorder 1-25,33-74,77-83,85-105,212-232
Order 26-32,75-76,84-84,106-211
Pfam Hmmer
PF07304 60-220 5.8e-136
SEG 57-74 ,190-203
Function
Function in SwissProt
Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity).