IDEAL List

IDEAL

IID50294
UniprotQ9QWF0
ProteinChromatin assembly factor 1 subunit A
GeneChaf1a
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

911

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 210-238 Hetero trimer : P83917

Evidence NMR 1s4z C Reference

Region 1s4z C 210-238 order

Region 1s4z C 210-214 high_rmsd

Region 1s4z C 233-238 high_rmsd

Seqphosphorylation

190-190 Phosphoserine

208-208 Phosphoserine

293-293 Phosphoserine

776-776 Phosphoserine

838-838 Phosphothreonine

Prediction

NeProc

Disorder 1-23,28-307,431-444,480-525,579-655,699-761,813-911

Order 24-27,308-430,445-479,526-578,656-698,762-812

ProS 4-23,28-45,59-74,79-100,108-114,121-124,162-166,182-186,199-228,441-444,480-525,579-583,590-594,611-621,635-650,714-743,813-817,848-859,870-877,884-893

AlphaFold

Disorder 1-319,426-429,431-444,447-447,455-456,462-462,464-465,485-485,494-533,584-584,586-614,617-618,620-632,654-658,671-676,690-704,744-763,787-787,818-911

Order 320-425,430-430,445-446,448-454,457-461,463-463,466-484,486-493,534-583,585-585,615-616,619-619,633-653,659-670,677-689,705-743,764-786,788-817

SEG 7-14 ,263-286 ,320-423 ,466-481 ,574-612 ,876-886

Function

Function in SwissProt

Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.