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IID50295
UniprotQ9VMA3
ProteinProtein cup
Genecup
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1117
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 296-425 Hetero dimer : IID50283Complex
 Evidence X-RAY 4axg C Reference
       Region 4axg C 296-317 disorder
       Region 4axg C 318-339 order
       Region 4axg C 340-361 disorder
       Region 4axg C 362-376 order
       Region 4axg C 377-425 disorder
Seq 296-425 Hetero dimer : IID50283Complex
 Evidence X-RAY 4axg D Reference
       Region 4axg D 296-324 disorder
       Region 4axg D 325-339 order
       Region 4axg D 340-425 disorder
Seqphosphorylation
    263-263 Phosphoserine
    270-270 Phosphoserine
    524-524 Phosphoserine
    523-523 Phosphoserine
    520-520 Phosphoserine
    513-513 Phosphoserine
    509-509 Phosphoserine
    503-503 Phosphothreonine
    350-350 Phosphoserine
    347-347 Phosphoserine
 
Prediction
NeProc
Disorder 1-100,138-175,226-235,244-264,273-321,378-574,580-586,593-1117
Order 106-137,176-225,236-243,265-272,322-377,575-579,587-592
ProS 1-54,71-74,84-96,138-144,153-165,244-264,278-283,305-315,378-424,435-460,465-574,580-586,593-599,611-623,670-702,709-722,730-736,744-772,783-796,805-821,854-876,885-895,954-972,978-984,1015-1029,1044-1054,1070-1073,1093-1098,1111-1117
AlphaFold
Disorder 1-54,58-58,60-97,100-121,139-191,212-320,346-356,377-532,547-552,554-567,569-569,571-734,736-760,771-810,903-919,927-927,932-953,981-1117
Order 55-57,59-59,98-99,122-138,192-211,321-345,357-376,533-546,553-553,568-568,570-570,735-735,761-770,811-902,920-926,928-931,954-980
SEG 55-63 ,94-104 ,390-399 ,415-429 ,640-652 ,677-688 ,692-712 ,725-729 ,815-835 ,898-907 ,988-1002 ,1061-1087
Function
Function in SwissProt
Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos (PubMed:9118812). Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation (PubMed:21937713). Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G (PubMed:14685270, PubMed:15465908, PubMed:21081899). This may contribute to translational repression but does not appear to be necessary for it to occur (PubMed:21081899). Can promote translational repression independently of deadenylation and eIF4E1 binding (PubMed:21937713). Required for correct localization of eIF4E1 in the developing oocyte (PubMed:15465908). Required for translational repression of oskar (osk) mRNA (PubMed:14691132, PubMed:14723848). Also required for the translational repression of nanos (nos) mRNA (PubMed:21081899). Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development (PubMed:22454519, PubMed:17277377). Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte (PubMed:22164257). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition (PubMed:28875934).