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IID50296
UniprotD0PV95
ProteinATP-dependent RNA helicase laf-1
Genelaf-1
OrganismCaenorhabditis elegans
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
708
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-168
 Evidence CD Reference
       Region 1-168 disorder
 
Prediction
NeProc
Disorder 1-188,629-708
Order 189-299,309-628
ProS 1-11,20-29,44-188,645-694,705-708
AlphaFold
Disorder 1-185,204-211,300-300,305-305,307-311,353-354,460-460,491-491,551-557,559-559,586-587,626-708
Order 186-203,212-299,301-304,306-306,312-352,355-459,461-490,492-550,558-558,560-585,588-625
Pfam Hmmer
PF00270 255-442 3.6e-57
PF00271 511-587 5e-36
SEG 3-21 ,28-95 ,97-132 ,624-650 ,655-698
Function
Function in SwissProt
Multifunctional ATP-dependent RNA helicase (PubMed:27546789). Plays a role in RNA remodeling, but is not required for RNA unwinding (PubMed:27546789). Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA (PubMed:26015579, PubMed:27546789). This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing (PubMed:27546789). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By similarity). Involved in both stress and inflammatory responses (By similarity). Promotes liquid-liquid phase separation of P granules, which is a process important for intracellular organization and stress granule assembly (PubMed:26015579). Required for embryonic development (PubMed:19361491, PubMed:26015579). Plays a role in sexual cell fate determination by negatively regulating the translation of the sex determining protein tra-2 (PubMed:9043090, PubMed:9321409, PubMed:26015579). May play a protective role in the response to heat and oxidative stress (PubMed:24844228). May negatively regulate extrinsic apoptotic signaling pathway via death domain receptors. May be involved in mitotic chromosome segregation (By similarity).