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IID50299
 UniprotO13936
ProteinTranscription elongation factor spt5
Genespt5
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
990
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 827-844 Hetero dimer : IID50316Complex
 Evidence X-RAY 4pz8 B Reference
       Region 4pz8 B 827-828 disorder
       Region 4pz8 B 829-832 order
       Region 4pz8 B 833-844 disorder
Seqphosphorylation
    36-36 Phosphoserine
 
Prediction
NeProc
Disorder 1-84,131-138,167-230,694-723,786-990
Order 85-130,139-166,231-461,468-693,724-785
ProS 170-196,202-230,694-700,786-800,807-990
AlphaFold
Disorder 1-186,214-227,328-333,376-385,451-470,572-577,694-726,795-990
Order 187-213,228-327,334-375,386-450,471-571,578-693,727-794
Pfam Hmmer
PF03439 209-251 4.1e-18
PF03439 287-333 8.1e-21
PF00467 334-369 0.00031
PF00467 521-554 6.4e-09
PF00467 728-761 3e-05
SEG 75-129 ,131-143 ,148-177 ,324-335 ,645-654 ,960-975
Function
Function in SwissProt
The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).