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IID50304
UniprotO54952
ProteinBreast cancer type 1 susceptibility protein homolog
GeneBrca1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1817
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1589-1817 Monomer :
 Evidence X-RAY 1l0b A Reference
       Region 1l0b A 1589-1590 disorder
       Region 1l0b A 1591-1702 order
       Region 1l0b A 1703-1704 disorder
       Region 1l0b A 1705-1756 order
       Region 1l0b A 1757-1775 disorder
       Region 1l0b A 1776-1801 order
       Region 1l0b A 1802-1817 disorder
Seqphosphorylation
    1351-1351 Phosphothreonine
    1482-1482 Phosphoserine
    1414-1414 Phosphoserine
    1380-1380 Phosphoserine
    114-114 Phosphoserine
    1344-1344 Phosphoserine
    1304-1304 Phosphoserine
    1298-1298 Phosphoserine
    1242-1242 Phosphoserine
    1181-1181 Phosphoserine
    1155-1155 Phosphoserine
    1153-1153 Phosphoserine
    975-975 Phosphoserine; by CHEK2
    717-717 Phosphoserine
    706-706 Phosphoserine
    686-686 Phosphoserine
    393-393 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-4,106-437,442-451,457-464,480-504,518-841,871-938,943-1353,1382-1592,1806-1817
Order 5-105,438-441,452-456,465-479,505-517,842-870,939-942,1354-1381,1593-1805
ProS 106-109,117-130,141-149,161-168,175-206,213-351,360-437,442-451,457-464,480-504,518-639,647-664,671-841,871-880,886-938,943-983,988-1077,1082-1168,1186-1198,1226-1234,1243-1260,1285-1318,1344-1353,1397-1401,1416-1423,1433-1451,1464-1494,1503-1528,1539-1573,1809-1817
Pfam Hmmer
PF00097 24-64 1.5e-11
PF00533 1588-1669 2.9e-12
PF00533 1701-1787 6.8e-11
SEG 105-120 ,744-760 ,891-905 ,1174-1186
Function
Function in SwissProt
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.