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IID50305
 UniprotO77448
ProteinTelomerase reverse transcriptase
GeneTERT
OrganismTetrahymena thermophila
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1117
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-191 Monomer :
 Evidence X-RAY 2b2a C Reference
       Region 2b2a C 2-11 disorder
       Region 2b2a C 12-77 order
       Region 2b2a C 78-86 disorder
       Region 2b2a C 87-101 order
       Region 2b2a C 102-102 disorder
       Region 2b2a C 103-121 order
       Region 2b2a C 122-127 disorder
       Region 2b2a C 128-177 order
       Region 2b2a C 178-184 disorder
       Region 2b2a C 185-191 order
 Evidence X-RAY 2b2a B Reference
       Region 2b2a B 2-13 disorder
       Region 2b2a B 14-77 order
       Region 2b2a B 78-86 disorder
       Region 2b2a B 87-101 order
       Region 2b2a B 102-102 disorder
       Region 2b2a B 103-121 order
       Region 2b2a B 122-127 disorder
       Region 2b2a B 128-177 order
       Region 2b2a B 178-185 disorder
       Region 2b2a B 186-191 order
 Evidence X-RAY 2b2a A Reference
       Region 2b2a A 2-12 disorder
       Region 2b2a A 13-77 order
       Region 2b2a A 78-86 disorder
       Region 2b2a A 87-121 order
       Region 2b2a A 122-127 disorder
       Region 2b2a A 128-191 order
Seqdisorder 1-12,182-191
 Evidence NMR Reference
       Region 1-12 disorder
       Region 182-191 disorder
Seq 254-519 Monomer :
 Evidence X-RAY 2r4g A Reference
       Region 2r4g A 254-258 disorder
       Region 2r4g A 259-265 order
       Region 2r4g A 266-276 disorder
       Region 2r4g A 277-519 order
 
Prediction
NeProc
Disorder 184-302,341-357,536-557,665-695,910-921,1006-1010,1111-1117
Order 1-183,303-340,358-535,558-664,696-909,922-1005,1011-1110
ProS 184-302,536-557,665-695,910-921,1006-1010,1111-1117
AlphaFold
Disorder 1-157,159-167,169-219,233-297,351-357,436-443,519-526,552-557,577-578,580-583,653-653,655-696,707-730,732-732,735-736,858-864,892-895,908-910,927-927,940-940,972-972,1006-1018,1020-1021,1041-1047,1065-1117
Order 158-158,168-168,220-232,298-350,358-435,444-518,527-551,558-576,579-579,584-652,654-654,697-706,731-731,733-734,737-857,865-891,896-907,911-926,928-939,941-971,973-1005,1019-1019,1022-1040,1048-1064
Pfam Hmmer
PF00078 527-881 0.00027
SEG 1-13 ,201-211 ,505-519
Function
Function in SwissProt
Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).