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IID50307
 UniprotP04819
ProteinDNA ligase 1
GeneCDC9
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
755
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 32-53 Hetero hexamer : P15873
 Evidence X-RAY 2od8 B Reference
       Region 2od8 B 32-34 disorder
       Region 2od8 B 35-45 order
       Region 2od8 B 46-53 disorder
SeqProS possible 38-45 PIP box Hetero hexamer : P15873
       Region 2od8 B 35-45 order
Seqphosphorylation
    58-58 Phosphoserine
    75-75 Phosphoserine
    119-119 Phosphoserine
    123-123 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-126,249-256,275-278,334-341,751-755
Order 127-248,257-274,279-333,342-750
ProS 1-12,275-278,751-755
AlphaFold
Disorder 1-141,248-252,335-340,601-606,751-755
Order 142-247,253-334,341-600,607-750
Pfam Hmmer
PF04675 146-325 1.1e-97
PF01068 393-598 2.6e-98
PF04679 623-688 3.5e-28
SEG 15-37 ,102-114 ,202-214 ,615-629
Function
Function in SwissProt
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. The mitochondrial form is required for mitochondrial DNA maintenance but is non-essential while the nuclear form is essential for cell viability.