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IID50309
 UniprotP0DP33
ProteinCalmodulin-1
Genecalm1
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
149
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-149 Hetero dimer :
 Evidence X-RAY 1iq5 A Reference
       Region 1iq5 A 1-4 disorder
       Region 1iq5 A 5-148 order
       Region 1iq5 A 149-149 disorder
Seq 2-77 Monomer :
 Evidence NMR 1f70 A Reference
       Region 1f70 A 2-77 order
Seq 2-81 Hetero dimer : IID00013Complex
 Evidence NMR 2llo A Reference
       Region 2llo A 2-81 order
Seq 2-149 Hetero dimer : Q62768
 Evidence NMR 2kdu A Reference
       Region 2kdu A 2-149 order
Seq 2-149 Hetero trimer : IID50189Complex
 Evidence NMR 1nwd A Reference
       Region 1nwd A 2-149 order
       Region 1nwd A 2-4 high_rmsd
Seq 2-149 Hetero tetramer : Q9WTI7
 Evidence X-RAY 4r8g H Reference
       Region 4r8g H 2-131 order
       Region 4r8g H 132-134 disorder
       Region 4r8g H 135-148 order
       Region 4r8g H 149-149 disorder
 Evidence X-RAY 4r8g B Reference
       Region 4r8g B 2-3 disorder
       Region 4r8g B 4-77 order
       Region 4r8g B 78-80 disorder
       Region 4r8g B 81-130 order
       Region 4r8g B 131-135 disorder
       Region 4r8g B 136-147 order
       Region 4r8g B 148-149 disorder
 Evidence X-RAY 4r8g A Reference
       Region 4r8g A 2-3 disorder
       Region 4r8g A 4-147 order
       Region 4r8g A 148-149 disorder
Seq 2-149 Hetero dimer : IID00510Complex
 Evidence NMR 1cff A Reference
       Region 1cff A 2-149 order
Seq 2-149 Monomer :
 Evidence NMR 1x02 A Reference
       Region 1x02 A 2-149 order
 Evidence NMR 1mux A Reference
       Region 1mux A 2-149 order
 Evidence NMR 1dmo A Reference
       Region 1dmo A 2-149 order
 Evidence NMR 1cfd A Reference
       Region 1cfd A 2-149 order
 Evidence NMR 1cfc A Reference
       Region 1cfc A 2-149 order
Seq 2-149 Hetero dimer : IID50188Complex
 Evidence NMR 1sy9 A Reference
       Region 1sy9 A 2-149 order
       Region 1sy9 A 2-4 high_rmsd
Seq 2-149 Hetero dimer : P78352
 Evidence NMR 2mes A Reference
       Region 2mes A 2-4 disorder
       Region 2mes A 5-148 order
       Region 2mes A 149-149 disorder
 Evidence NMR 5j7j A Reference
       Region 5j7j A 2-4 disorder
       Region 5j7j A 5-148 order
       Region 5j7j A 149-149 disorder
Seq 2-149 Hetero trimer : IID00013Complex
 Evidence NMR 5t0x A Reference
       Region 5t0x A 2-149 order
Seq 2-149 Hetero dimer : IID50177Complex
 Evidence NMR 1ckk A Reference
       Region 1ckk A 2-149 order
       Region 1ckk A 2-5 high_rmsd
       Region 1ckk A 149-149 high_rmsd
Seq 6-149 Hetero dimer : P40136
 Evidence X-RAY 1y0v M Reference
       Region 1y0v M 6-149 order
 Evidence X-RAY 1y0v L Reference
       Region 1y0v L 6-149 order
 Evidence X-RAY 1y0v K Reference
       Region 1y0v K 6-149 order
 Evidence X-RAY 1y0v J Reference
       Region 1y0v J 6-149 order
 Evidence X-RAY 1y0v I Reference
       Region 1y0v I 6-149 order
 Evidence X-RAY 1y0v H Reference
       Region 1y0v H 6-149 order
Seq 79-149 Monomer :
 Evidence NMR 1f71 A Reference
       Region 1f71 A 83-149 order
 Evidence NMR 2rrt A Reference
       Region 2rrt A 79-149 order
       Region 2rrt A 79-80 high_rmsd
       Region 2rrt A 133-133 high_rmsd
Seq 80-146 Hetero dimer : P0DKX7
 Evidence X-RAY 2col B Reference
       Region 2col B 80-146 order
Seq 83-149 Hetero dimer : IID50181Complex
 Evidence NMR 2k3s B Reference
       Region 2k3s B 83-149 order
Seq 83-149 Hetero dimer : IID00013Complex
 Evidence NMR 2llq A Reference
       Region 2llq A 83-149 order
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-2,149-149
Order 3-148
ProS 1-2
AlphaFold
Disorder 1-5,75-82,148-149
Order 6-74,83-147
Pfam Hmmer
PF00036 12-40 2.1e-09
PF00036 48-76 5.1e-09
PF00036 85-113 5e-10
PF00036 121-149 9.4e-10
Function
Function in SwissProt
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
Biological Process
See also
Diagram with PDB data
ESR1/ESR1/calm1Solution NMR-derived structure of calmodulin bound with ER alpha peptides