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IID50314
 UniprotP33411
ProteinPre-mRNA-splicing factor 18
GenePRP18
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
251
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 79-251 Homo dimer :
 Evidence X-RAY 1dvk B Reference
       Region 1dvk B 79-198 order
       Region 1dvk B 199-217 disorder
       Region 1dvk B 218-247 order
       Region 1dvk B 248-251 disorder
 Evidence X-RAY 1dvk A Reference
       Region 1dvk A 79-197 order
       Region 1dvk A 198-217 disorder
       Region 1dvk A 218-247 order
       Region 1dvk A 248-251 disorder
 
Prediction
NeProc
Disorder 1-99,246-251
Order 100-245
ProS 1-51,59-84,92-99,246-251
AlphaFold
Disorder 1-4,23-65,197-219,249-251
Order 5-22,66-196,220-248
Pfam Hmmer
PF02840 100-247 3.5e-97
Function
Function in SwissProt
Component of the U4/U5/U6 snRNP, binding principally to the u5 snRNP. It is not absolutely required for the second step of pre-mRNA splicing at low temperatures but is required at higher temperatures. It may stabilize a particular conformation of the U5 snRNP or orient the U5 snRNP within the U4/U5/U6 snRNP or within the spliceosome.