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IID50318
 UniprotP46662
ProteinMerlin
GeneNf2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
596
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-313 Hetero dimer : IID00743Complex
 Evidence X-RAY 4p7i B Reference
       Region 4p7i B 1-20 disorder
       Region 4p7i B 21-312 order
       Region 4p7i B 313-313 disorder
Seq 1-313 Hetero dimer : IID00743Complex
 Evidence X-RAY 4p7i A Reference
       Region 4p7i A 1-18 disorder
       Region 4p7i A 19-312 order
       Region 4p7i A 313-313 disorder
Seq 18-340 Monomer :
 Evidence X-RAY 1isn A Reference
       Region 1isn A 18-340 order
Seq 19-314 Hetero heptamer : IID00743Complex
 Evidence X-RAY 3wa0 A Reference
       Region 3wa0 A 19-23 disorder
       Region 3wa0 A 24-312 order
       Region 3wa0 A 313-314 disorder
 Evidence X-RAY 3wa0 B Reference
       Region 3wa0 B 19-22 disorder
       Region 3wa0 B 23-312 order
       Region 3wa0 B 313-314 disorder
 Evidence X-RAY 3wa0 C Reference
       Region 3wa0 C 19-20 disorder
       Region 3wa0 C 21-313 order
       Region 3wa0 C 314-314 disorder
 Evidence X-RAY 3wa0 D Reference
       Region 3wa0 D 19-313 order
       Region 3wa0 D 314-314 disorder
 Evidence X-RAY 3wa0 E Reference
       Region 3wa0 E 19-20 disorder
       Region 3wa0 E 21-312 order
       Region 3wa0 E 313-314 disorder
 Evidence X-RAY 3wa0 F Reference
       Region 3wa0 F 19-20 disorder
       Region 3wa0 F 21-311 order
       Region 3wa0 F 312-314 disorder
Seqphosphorylation
    13-13 Phosphoserine
    518-518 Phosphoserine; by PAK
 
Prediction
NeProc
Disorder 1-19,479-513
Order 20-478,514-596
ProS 503-513
AlphaFold
Disorder 1-16,416-418,479-510,569-572
Order 17-415,419-478,511-568,573-596
Pfam Hmmer
PF00373 24-222 1.9e-135
PF00769 226-596 3.8e-214
SEG 346-361 ,392-408 ,479-501
Function
Function in SwissProt
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex (By similarity). Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.