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IID50321
UniprotP63086
ProteinMitogen-activated protein kinase 1
GeneMapk1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
358
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-358 Hetero dimer : IID50334Complex
 Evidence X-RAY 3o71 A Reference
       Region 3o71 A 1-8 disorder
       Region 3o71 A 9-174 order
       Region 3o71 A 175-179 disorder
       Region 3o71 A 180-200 order
       Region 3o71 A 201-201 disorder
       Region 3o71 A 202-354 order
       Region 3o71 A 355-358 disorder
Seq 1-358 Monomer :
 Evidence X-RAY 2z7l A Reference
       Region 2z7l A 1-15 disorder
       Region 2z7l A 16-31 order
       Region 2z7l A 32-34 disorder
       Region 2z7l A 35-327 order
       Region 2z7l A 328-335 disorder
       Region 2z7l A 336-355 order
       Region 2z7l A 356-358 disorder
 Evidence X-RAY 1gol A Reference
       Region 1gol A 1-1 disorder
       Region 1gol A 2-358 order
 Evidence X-RAY 3erk A Reference
       Region 3erk A 1-5 disorder
       Region 3erk A 6-355 order
       Region 3erk A 356-358 disorder
 Evidence X-RAY 2erk A Reference
       Region 2erk A 1-5 disorder
       Region 2erk A 6-358 order
 Evidence X-RAY 1erk A Reference
       Region 1erk A 1-1 disorder
       Region 1erk A 2-358 order
 Evidence X-RAY 3c9w B Reference
       Region 3c9w B 2-5 disorder
       Region 3c9w B 6-174 order
       Region 3c9w B 175-187 disorder
       Region 3c9w B 188-354 order
       Region 3c9w B 355-358 disorder
 Evidence X-RAY 3c9w A Reference
       Region 3c9w A 2-5 disorder
       Region 3c9w A 6-174 order
       Region 3c9w A 175-187 disorder
       Region 3c9w A 188-354 order
       Region 3c9w A 355-358 disorder
Seq 2-358 Hetero dimer : IID50335Complex
 Evidence X-RAY 2fys A Reference
       Region 2fys A 2-7 disorder
       Region 2fys A 8-200 order
       Region 2fys A 201-201 disorder
       Region 2fys A 202-356 order
       Region 2fys A 357-358 disorder
 Evidence X-RAY 2fys B Reference
       Region 2fys B 2-7 disorder
       Region 2fys B 8-175 order
       Region 2fys B 176-183 disorder
       Region 2fys B 184-328 order
       Region 2fys B 329-332 disorder
       Region 2fys B 333-357 order
       Region 2fys B 358-358 disorder
Seq 2-358 Hetero dimer : IID00617Complex
 Evidence X-RAY 2gph A Reference
       Region 2gph A 2-9 disorder
       Region 2gph A 10-354 order
       Region 2gph A 355-358 disorder
Seqphosphorylation
    27-27 Phosphoserine; by SGK1
    183-183 Phosphothreonine
    185-185 Phosphotyrosine
    188-188 Phosphothreonine; by autocatalysis
    244-244 Phosphoserine
    246-246 Phosphoserine
    282-282 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-8,357-358
Order 9-356
ProS 357-358
AlphaFold
Disorder 1-7,180-184,357-358
Order 8-179,185-356
Pfam Hmmer
PF00069 23-311 2.3e-88
SEG 2-7 ,330-344
Function
Function in SwissProt
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.