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IID50321
 UniprotP63086
ProteinMitogen-activated protein kinase 1
GeneMapk1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
358
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-358 Monomer :
 Evidence X-RAY 1gol A Reference
       Region 1gol A 1-1 disorder
       Region 1gol A 2-358 order
 Evidence X-RAY 2erk A Reference
       Region 2erk A 1-5 disorder
       Region 2erk A 6-358 order
 Evidence X-RAY 2z7l A Reference
       Region 2z7l A 1-15 disorder
       Region 2z7l A 16-31 order
       Region 2z7l A 32-34 disorder
       Region 2z7l A 35-327 order
       Region 2z7l A 328-335 disorder
       Region 2z7l A 336-355 order
       Region 2z7l A 356-358 disorder
 Evidence X-RAY 3c9w A Reference
       Region 3c9w A 2-5 disorder
       Region 3c9w A 6-174 order
       Region 3c9w A 175-187 disorder
       Region 3c9w A 188-354 order
       Region 3c9w A 355-358 disorder
 Evidence X-RAY 3c9w B Reference
       Region 3c9w B 2-5 disorder
       Region 3c9w B 6-174 order
       Region 3c9w B 175-187 disorder
       Region 3c9w B 188-354 order
       Region 3c9w B 355-358 disorder
 Evidence X-RAY 3erk A Reference
       Region 3erk A 1-5 disorder
       Region 3erk A 6-355 order
       Region 3erk A 356-358 disorder
Seq 1-358
 Evidence X-RAY 1erk A Reference
       Region 1erk A 1-1 disorder
       Region 1erk A 2-358 order
Seq 1-358 Hetero dimer : IID50334Complex
 Evidence X-RAY 3o71 A Reference
       Region 3o71 A 1-8 disorder
       Region 3o71 A 9-174 order
       Region 3o71 A 175-179 disorder
       Region 3o71 A 180-200 order
       Region 3o71 A 201-201 disorder
       Region 3o71 A 202-354 order
       Region 3o71 A 355-358 disorder
Seq 2-358 Hetero dimer : IID00617Complex
 Evidence X-RAY 2gph A Reference
       Region 2gph A 2-9 disorder
       Region 2gph A 10-354 order
       Region 2gph A 355-358 disorder
Seq 2-358 Hetero dimer : IID50335Complex
 Evidence X-RAY 2fys B Reference
       Region 2fys B 2-7 disorder
       Region 2fys B 8-175 order
       Region 2fys B 176-183 disorder
       Region 2fys B 184-328 order
       Region 2fys B 329-332 disorder
       Region 2fys B 333-357 order
       Region 2fys B 358-358 disorder
 Evidence X-RAY 2fys A Reference
       Region 2fys A 2-7 disorder
       Region 2fys A 8-200 order
       Region 2fys A 201-201 disorder
       Region 2fys A 202-356 order
       Region 2fys A 357-358 disorder
Seqphosphorylation
    27-27 Phosphoserine; by SGK1
    183-183 Phosphothreonine
    185-185 Phosphotyrosine
    188-188 Phosphothreonine; by autocatalysis
    244-244 Phosphoserine
    246-246 Phosphoserine
    282-282 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-8,357-358
Order 9-356
ProS 357-358
AlphaFold
Disorder 1-7,180-184,357-358
Order 8-179,185-356
Pfam Hmmer
PF00069 23-311 2.3e-88
SEG 2-7 ,330-344
Function
Function in SwissProt
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.