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IID50331
 UniprotQ61337
ProteinBcl2-associated agonist of cell death
GeneBad
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
204
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-182
 Evidence CD Reference
       Region 1-182 disorder
Seq 137-163 Hetero dimer : IID50336Complex
 Evidence X-RAY 2bzw B Reference
       Region 2bzw B 137-163 order
SeqProS verified 137-163 Hetero dimer : IID50336Complex
       Region 2bzw B 137-163 order
       Region 1-182 disorder
Seqphosphorylation
    170-170 Phosphoserine
    67-67 Phosphoserine
    155-155 Phosphoserine; by PKA and PKB
    155-155 Phosphoserine
    136-136 Phosphoserine; by PKA
    134-134 Phosphoserine
    128-128 Phosphoserine
    112-112 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 1-156,161-204
Order 157-160
ProS 14-49,62-65,72-79,106-114,127-156,161-169,176-196
AlphaFold
Disorder 1-2,7-139,159-166,168-181,195-204
Order 3-6,140-158,167-167,182-194
SEG 118-126
Function
Function in SwissProt
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.