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IID50333
 UniprotQ61823
ProteinProgrammed cell death protein 4
GenePdcd4
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
469
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 120-469 Hetero trimer : P60842
 Evidence X-RAY 3eiq C Reference
       Region 3eiq C 120-160 disorder
       Region 3eiq C 161-283 order
       Region 3eiq C 284-286 disorder
       Region 3eiq C 287-304 order
       Region 3eiq C 305-313 disorder
       Region 3eiq C 314-450 order
       Region 3eiq C 451-469 disorder
Seq 319-449 Hetero dimer : IID00729Complex
 Evidence NMR 2kzt B Reference
       Region 2kzt B 319-449 order
Seq 319-469 Monomer :
 Evidence NMR 2hm8 A Reference
       Region 2hm8 A 319-449 order
 Evidence X-RAY 2nsz A Reference
       Region 2nsz A 322-450 order
 Evidence X-RAY 2ios A Reference
       Region 2ios A 320-322 disorder
       Region 2ios A 323-448 order
       Region 2ios A 449-469 disorder
 Evidence X-RAY 2ion A Reference
       Region 2ion A 320-321 disorder
       Region 2ion A 322-448 order
       Region 2ion A 449-467 disorder
 Evidence X-RAY 2iol B Reference
       Region 2iol B 320-321 disorder
       Region 2iol B 322-448 order
       Region 2iol B 449-469 disorder
 Evidence X-RAY 2iol A Reference
       Region 2iol A 320-321 disorder
       Region 2iol A 322-448 order
       Region 2iol A 449-469 disorder
Seqphosphorylation
    94-94 Phosphoserine
    25-25 Phosphoserine
    67-67 Phosphoserine; by PKB and RPS6KB1
    68-68 Phosphoserine
    71-71 Phosphoserine
    76-76 Phosphoserine
    78-78 Phosphoserine
    152-152 Phosphotyrosine
    313-313 Phosphoserine
    317-317 Phosphoserine
    457-457 Phosphoserine; by PKB
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-156,307-315,463-469
Order 157-306,321-462
ProS 1-21,40-45,53-62,119-128,137-156,307-315,463-469
AlphaFold
Disorder 1-127,130-134,147-155,307-313,451-469
Order 128-129,135-146,156-306,314-450
Pfam Hmmer
PF02847 164-275 1.1e-43
PF02847 327-440 1e-47
SEG 66-82 ,96-122
Function
Function in SwissProt
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.