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IID50334
 UniprotQ63155
ProteinNetrin receptor DCC
GeneDcc
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1445
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 39-421 Monomer :
 Evidence X-RAY 3laf A Reference
       Region 3laf A 39-420 order
       Region 3laf A 421-421 disorder
Seq 1140-1166 Hetero dimer : IID50321Complex
 Evidence X-RAY 3o71 B Reference
       Region 3o71 B 1140-1148 disorder
       Region 3o71 B 1149-1156 order
       Region 3o71 B 1157-1166 disorder
Seqphosphorylation
    1267-1267 Phosphoserine; by MAPK1
    1187-1187 Phosphothreonine; by MAPK1
    1178-1178 Phosphoserine; by MAPK1
 
Prediction
NeProc
Disorder 1-4,820-824,1045-1062,1072-1098,1122-1434
Order 5-421,429-818,825-1044,1063-1071,1099-1121,1435-1445
ProS 1-4,820-824,1054-1059,1072-1098,1122-1124,1146-1158,1173-1192,1207-1215,1246-1252,1270-1274,1325-1347,1406-1410,1415-1434
AlphaFold
Disorder 1-35,184-185,373-376,419-426,473-473,523-526,667-669,719-721,751-751,765-766,817-845,868-878,890-893,933-933,1044-1445
Order 36-183,186-372,377-418,427-472,474-522,527-666,670-718,722-750,752-764,767-816,846-867,879-889,894-932,934-1043
Pfam Hmmer
PF07679 40-136 0.00081
PF07679 140-230 1.1e-14
PF07679 240-327 6.1e-20
PF07679 331-417 2.1e-18
PF00041 429-514 8.3e-15
PF00041 528-610 4.5e-20
PF00041 622-708 1.2e-18
PF00041 726-808 3e-07
PF00041 843-932 4.4e-06
PF00041 944-1034 2.5e-16
PF06583 1073-1443 4.8e-241
SEG 288-299 ,420-432 ,753-765 ,1098-1120 ,1303-1316
Function
Function in SwissProt
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).