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IID50335
 UniprotQ64346
ProteinDual specificity protein phosphatase 6
GeneDusp6
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
381
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 60-76 Hetero dimer : IID50321Complex
 Evidence X-RAY 2fys C Reference
       Region 2fys C 60-63 disorder
       Region 2fys C 64-74 order
       Region 2fys C 75-76 disorder
 Evidence X-RAY 2fys D Reference
       Region 2fys D 60-63 disorder
       Region 2fys D 64-74 order
       Region 2fys D 75-76 disorder
 
Prediction
NeProc
Disorder 153-201,353-381
Order 1-152,202-352
ProS 197-201,353-381
AlphaFold
Disorder 1-15,58-73,75-88,90-91,103-112,150-205,350-381
Order 16-57,74-74,89-89,92-102,113-149,206-349
Pfam Hmmer
PF00581 19-142 0.00018
PF00782 206-346 1e-70
SEG 23-36 ,115-123 ,151-187
Function
Function in SwissProt
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity).