Search Keyword:


Search option:


IID50336
 UniprotQ64373
ProteinBcl-2-like protein 1
GeneBcl2l1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-196 Hetero dimer : IID50303Complex
 Evidence X-RAY 1pq1 A Reference
       Region 1pq1 A 1-28 order
       Region 1pq1 A 29-77 disorder
       Region 1pq1 A 78-196 order
Seq 1-196 Monomer :
 Evidence X-RAY 1pq0 A Reference
       Region 1pq0 A 1-1 disorder
       Region 1pq0 A 2-29 order
       Region 1pq0 A 30-80 disorder
       Region 1pq0 A 81-196 order
 Evidence X-RAY 3ilc A Reference
       Region 3ilc A 1-28 order
       Region 3ilc A 29-81 disorder
       Region 3ilc A 82-196 order
 Evidence X-RAY 3ilb N Reference
       Region 3ilb N 1-1 disorder
       Region 3ilb N 2-25 order
       Region 3ilb N 26-69 disorder
       Region 3ilb N 70-196 order
 Evidence X-RAY 3ilb A Reference
       Region 3ilb A 1-1 disorder
       Region 3ilb A 2-25 order
       Region 3ilb A 26-69 disorder
       Region 3ilb A 70-196 order
 Evidence X-RAY 3iih A Reference
       Region 3iih A 1-1 disorder
       Region 3iih A 2-27 order
       Region 3iih A 28-80 disorder
       Region 3iih A 81-196 order
 Evidence X-RAY 3iig A Reference
       Region 3iig A 1-1 disorder
       Region 3iig A 2-27 order
       Region 3iig A 28-81 disorder
       Region 3iig A 82-196 order
 Evidence X-RAY 3ihf D Reference
       Region 3ihf D 1-1 disorder
       Region 3ihf D 2-29 order
       Region 3ihf D 30-72 disorder
       Region 3ihf D 73-196 order
 Evidence X-RAY 3ihf C Reference
       Region 3ihf C 1-1 disorder
       Region 3ihf C 2-29 order
       Region 3ihf C 30-72 disorder
       Region 3ihf C 73-196 order
 Evidence X-RAY 3ihf B Reference
       Region 3ihf B 1-1 disorder
       Region 3ihf B 2-29 order
       Region 3ihf B 30-72 disorder
       Region 3ihf B 73-196 order
 Evidence X-RAY 3ihf A Reference
       Region 3ihf A 1-1 disorder
       Region 3ihf A 2-29 order
       Region 3ihf A 30-72 disorder
       Region 3ihf A 73-196 order
 Evidence X-RAY 3ihe A Reference
       Region 3ihe A 1-27 order
       Region 3ihe A 28-81 disorder
       Region 3ihe A 82-196 order
 Evidence X-RAY 3ihd A Reference
       Region 3ihd A 1-27 order
       Region 3ihd A 28-81 disorder
       Region 3ihd A 82-196 order
 Evidence X-RAY 3ihc A Reference
       Region 3ihc A 1-1 disorder
       Region 3ihc A 2-27 order
       Region 3ihc A 28-81 disorder
       Region 3ihc A 82-196 order
Seq 1-211 Hetero dimer : IID50331Complex
 Evidence X-RAY 2bzw A Reference
       Region 2bzw A 1-1 disorder
       Region 2bzw A 2-29 order
       Region 2bzw A 30-80 disorder
       Region 2bzw A 81-196 order
       Region 2bzw A 197-211 disorder
Seqphosphorylation
    62-62 Phosphoserine; by CDK1
    49-49 Phosphoserine; by PLK3
 
Prediction
NeProc
Disorder 16-21,28-82,200-212,231-233
Order 1-15,22-27,83-199,213-230
ProS 16-21,53-64,208-212,231-233
AlphaFold
Disorder 1-1,29-81,105-105,108-108,197-233
Order 2-28,82-104,106-107,109-196
Pfam Hmmer
PF02180 1-27 2.5e-14
PF00452 90-188 4.3e-59
SEG 31-48
Function
Function in SwissProt
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles (By similarity). May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).
Isoform Bcl-X(S) promotes apoptosis.