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IID50341
 UniprotQ8K368
ProteinFanconi anemia group I protein homolog
GeneFanci
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1330
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1302 Monomer :
 Evidence X-RAY 3s51 D Reference
       Region 3s51 D 1-100 disorder
       Region 3s51 D 101-250 order
       Region 3s51 D 251-257 disorder
       Region 3s51 D 258-401 order
       Region 3s51 D 402-410 disorder
       Region 3s51 D 411-553 order
       Region 3s51 D 554-562 disorder
       Region 3s51 D 563-683 order
       Region 3s51 D 684-691 disorder
       Region 3s51 D 692-714 order
       Region 3s51 D 715-730 disorder
       Region 3s51 D 731-784 order
       Region 3s51 D 785-797 disorder
       Region 3s51 D 798-886 order
       Region 3s51 D 887-901 disorder
       Region 3s51 D 902-934 order
       Region 3s51 D 935-944 disorder
       Region 3s51 D 945-1056 order
       Region 3s51 D 1057-1069 disorder
       Region 3s51 D 1070-1106 order
       Region 3s51 D 1107-1126 disorder
       Region 3s51 D 1127-1188 order
       Region 3s51 D 1189-1189 disorder
       Region 3s51 D 1190-1222 order
       Region 3s51 D 1223-1247 disorder
       Region 3s51 D 1248-1280 order
       Region 3s51 D 1281-1302 disorder
 Evidence X-RAY 3s51 C Reference
       Region 3s51 C 1-250 order
       Region 3s51 C 251-257 disorder
       Region 3s51 C 258-401 order
       Region 3s51 C 402-410 disorder
       Region 3s51 C 411-553 order
       Region 3s51 C 554-562 disorder
       Region 3s51 C 563-683 order
       Region 3s51 C 684-691 disorder
       Region 3s51 C 692-714 order
       Region 3s51 C 715-730 disorder
       Region 3s51 C 731-784 order
       Region 3s51 C 785-797 disorder
       Region 3s51 C 798-886 order
       Region 3s51 C 887-901 disorder
       Region 3s51 C 902-934 order
       Region 3s51 C 935-944 disorder
       Region 3s51 C 945-1056 order
       Region 3s51 C 1057-1069 disorder
       Region 3s51 C 1070-1106 order
       Region 3s51 C 1107-1126 disorder
       Region 3s51 C 1127-1188 order
       Region 3s51 C 1189-1189 disorder
       Region 3s51 C 1190-1222 order
       Region 3s51 C 1223-1247 disorder
       Region 3s51 C 1248-1280 order
       Region 3s51 C 1281-1302 disorder
 Evidence X-RAY 3s51 B Reference
       Region 3s51 B 1-63 disorder
       Region 3s51 B 64-250 order
       Region 3s51 B 251-257 disorder
       Region 3s51 B 258-401 order
       Region 3s51 B 402-410 disorder
       Region 3s51 B 411-553 order
       Region 3s51 B 554-562 disorder
       Region 3s51 B 563-683 order
       Region 3s51 B 684-691 disorder
       Region 3s51 B 692-714 order
       Region 3s51 B 715-730 disorder
       Region 3s51 B 731-784 order
       Region 3s51 B 785-797 disorder
       Region 3s51 B 798-886 order
       Region 3s51 B 887-901 disorder
       Region 3s51 B 902-934 order
       Region 3s51 B 935-944 disorder
       Region 3s51 B 945-1056 order
       Region 3s51 B 1057-1069 disorder
       Region 3s51 B 1070-1106 order
       Region 3s51 B 1107-1126 disorder
       Region 3s51 B 1127-1188 order
       Region 3s51 B 1189-1189 disorder
       Region 3s51 B 1190-1222 order
       Region 3s51 B 1223-1247 disorder
       Region 3s51 B 1248-1280 order
       Region 3s51 B 1281-1302 disorder
 Evidence X-RAY 3s51 A Reference
       Region 3s51 A 1-250 order
       Region 3s51 A 251-257 disorder
       Region 3s51 A 258-401 order
       Region 3s51 A 402-410 disorder
       Region 3s51 A 411-553 order
       Region 3s51 A 554-562 disorder
       Region 3s51 A 563-683 order
       Region 3s51 A 684-691 disorder
       Region 3s51 A 692-714 order
       Region 3s51 A 715-730 disorder
       Region 3s51 A 731-784 order
       Region 3s51 A 785-797 disorder
       Region 3s51 A 798-886 order
       Region 3s51 A 887-901 disorder
       Region 3s51 A 902-934 order
       Region 3s51 A 935-944 disorder
       Region 3s51 A 945-1056 order
       Region 3s51 A 1057-1069 disorder
       Region 3s51 A 1070-1106 order
       Region 3s51 A 1107-1126 disorder
       Region 3s51 A 1127-1188 order
       Region 3s51 A 1189-1189 disorder
       Region 3s51 A 1190-1222 order
       Region 3s51 A 1223-1247 disorder
       Region 3s51 A 1248-1280 order
       Region 3s51 A 1281-1302 disorder
 Evidence X-RAY 3s4z C Reference
       Region 3s4z C 1-250 order
       Region 3s4z C 251-257 disorder
       Region 3s4z C 258-401 order
       Region 3s4z C 402-410 disorder
       Region 3s4z C 411-553 order
       Region 3s4z C 554-562 disorder
       Region 3s4z C 563-683 order
       Region 3s4z C 684-691 disorder
       Region 3s4z C 692-714 order
       Region 3s4z C 715-730 disorder
       Region 3s4z C 731-784 order
       Region 3s4z C 785-797 disorder
       Region 3s4z C 798-886 order
       Region 3s4z C 887-901 disorder
       Region 3s4z C 902-934 order
       Region 3s4z C 935-944 disorder
       Region 3s4z C 945-1035 order
       Region 3s4z C 1036-1038 disorder
       Region 3s4z C 1039-1056 order
       Region 3s4z C 1057-1069 disorder
       Region 3s4z C 1070-1106 order
       Region 3s4z C 1107-1126 disorder
       Region 3s4z C 1127-1188 order
       Region 3s4z C 1189-1189 disorder
       Region 3s4z C 1190-1222 order
       Region 3s4z C 1223-1247 disorder
       Region 3s4z C 1248-1280 order
       Region 3s4z C 1281-1302 disorder
 Evidence X-RAY 3s4z B Reference
       Region 3s4z B 1-250 order
       Region 3s4z B 251-257 disorder
       Region 3s4z B 258-401 order
       Region 3s4z B 402-410 disorder
       Region 3s4z B 411-553 order
       Region 3s4z B 554-562 disorder
       Region 3s4z B 563-683 order
       Region 3s4z B 684-691 disorder
       Region 3s4z B 692-714 order
       Region 3s4z B 715-730 disorder
       Region 3s4z B 731-784 order
       Region 3s4z B 785-797 disorder
       Region 3s4z B 798-886 order
       Region 3s4z B 887-901 disorder
       Region 3s4z B 902-934 order
       Region 3s4z B 935-944 disorder
       Region 3s4z B 945-1035 order
       Region 3s4z B 1036-1038 disorder
       Region 3s4z B 1039-1056 order
       Region 3s4z B 1057-1069 disorder
       Region 3s4z B 1070-1106 order
       Region 3s4z B 1107-1126 disorder
       Region 3s4z B 1127-1188 order
       Region 3s4z B 1189-1189 disorder
       Region 3s4z B 1190-1222 order
       Region 3s4z B 1223-1247 disorder
       Region 3s4z B 1248-1280 order
       Region 3s4z B 1281-1302 disorder
 Evidence X-RAY 3s4z A Reference
       Region 3s4z A 1-250 order
       Region 3s4z A 251-257 disorder
       Region 3s4z A 258-401 order
       Region 3s4z A 402-410 disorder
       Region 3s4z A 411-553 order
       Region 3s4z A 554-562 disorder
       Region 3s4z A 563-683 order
       Region 3s4z A 684-691 disorder
       Region 3s4z A 692-714 order
       Region 3s4z A 715-730 disorder
       Region 3s4z A 731-784 order
       Region 3s4z A 785-797 disorder
       Region 3s4z A 798-886 order
       Region 3s4z A 887-901 disorder
       Region 3s4z A 902-934 order
       Region 3s4z A 935-944 disorder
       Region 3s4z A 945-1035 order
       Region 3s4z A 1036-1038 disorder
       Region 3s4z A 1039-1056 order
       Region 3s4z A 1057-1069 disorder
       Region 3s4z A 1070-1106 order
       Region 3s4z A 1107-1126 disorder
       Region 3s4z A 1127-1188 order
       Region 3s4z A 1189-1189 disorder
       Region 3s4z A 1190-1222 order
       Region 3s4z A 1223-1247 disorder
       Region 3s4z A 1248-1280 order
       Region 3s4z A 1281-1302 disorder
Seq 1-1302 Hetero dimer : IID50340Complex
 Evidence X-RAY 3s4w A Reference
       Region 3s4w A 1-250 order
       Region 3s4w A 251-257 disorder
       Region 3s4w A 258-401 order
       Region 3s4w A 402-410 disorder
       Region 3s4w A 411-683 order
       Region 3s4w A 684-694 disorder
       Region 3s4w A 695-790 order
       Region 3s4w A 791-797 disorder
       Region 3s4w A 798-886 order
       Region 3s4w A 887-901 disorder
       Region 3s4w A 902-1106 order
       Region 3s4w A 1107-1126 disorder
       Region 3s4w A 1127-1222 order
       Region 3s4w A 1223-1247 disorder
       Region 3s4w A 1248-1300 order
       Region 3s4w A 1301-1302 disorder
SeqProS verified 554-562 Hetero dimer : IID50340Complex
       Region 3s4w A 411-683 order
       Region 3s51 A 554-562 disorder
Seqphosphorylation
    555-555 Phosphoserine
    558-558 Phosphothreonine
    729-729 Phosphoserine
    948-948 Phosphothreonine
    1122-1122 Phosphoserine
 
Prediction
NeProc
Disorder 250-257,550-572,686-693,790-797,938-946,967-970,1222-1240,1296-1330
Order 1-249,262-407,413-450,456-549,573-685,694-789,798-890,900-937,947-966,971-1116,1121-1186,1191-1221,1241-1295
ProS 250-257,564-572,686-686,967-970,1296-1299,1326-1330
AlphaFold
Disorder 12-12,143-149,248-260,298-302,356-358,395-412,452-454,547-576,684-693,788-800,894-899,935-943,970-971,1106-1126,1186-1189,1220-1243,1279-1330
Order 1-11,13-142,150-247,261-297,303-355,359-394,413-451,455-546,577-683,694-787,801-893,900-934,944-969,972-1105,1127-1185,1190-1219,1244-1278
SEG 635-646 ,688-706 ,756-767 ,892-902 ,939-942 ,961-968 ,1299-1307
Function
Function in SwissProt
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.
Biological Process
Diagram with PDB data
Fanci/Fancd2Structure of the FANCI-FANCD2 complex